Bidirectional dopamine modulation of excitatory and inhibitory synaptic inputs to subthalamic neuron subsets containing α4β2 or α7 nAChRs.
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
/ pharmacology
Animals
Benzazepines
/ pharmacology
Dopamine
/ metabolism
Dopamine D2 Receptor Antagonists
/ pharmacology
Excitatory Postsynaptic Potentials
/ drug effects
Inhibitory Postsynaptic Potentials
/ drug effects
Mice
Mice, Knockout
Oxidopamine
/ pharmacology
Piperazines
/ pharmacology
Quinpirole
/ pharmacology
Receptors, Dopamine D1
/ agonists
Receptors, Dopamine D2
/ physiology
Receptors, Nicotinic
/ genetics
Reserpine
/ pharmacology
Subthalamic Nucleus
/ physiology
Synaptic Transmission
/ drug effects
alpha7 Nicotinic Acetylcholine Receptor
/ physiology
Dopamine receptors
Nicotinic acetylcholine receptor
Subthalamic nucleus
α4β2
α7
Journal
Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
10
08
2018
revised:
10
01
2019
accepted:
14
01
2019
pubmed:
21
1
2019
medline:
28
12
2019
entrez:
21
1
2019
Statut:
ppublish
Résumé
The subthalamic nucleus (STN) possesses microcircuits distinguished by subtypes of nicotinic acetylcholine receptors (nAChRs). Although dysfunction of the STN is well-known in Parkinson's disease, there is still little information about whether dopamine differentially modulates excitatory and inhibitory synaptic inputs to STN neurons expressing different nAChR subtypes. To address this issue, we performed brain slice patch-clamp recordings on STN neurons, while we pharmacologically manipulated dopaminergic inputs. In STN neuron subsets containing either α4β2 or α7 nAChRs, D
Identifiants
pubmed: 30660626
pii: S0028-3908(18)30496-9
doi: 10.1016/j.neuropharm.2019.01.015
pii:
doi:
Substances chimiques
Benzazepines
0
Dopamine D2 Receptor Antagonists
0
Piperazines
0
Receptors, Dopamine D1
0
Receptors, Dopamine D2
0
Receptors, Nicotinic
0
SCH 23390
0
alpha7 Nicotinic Acetylcholine Receptor
0
nicotinic receptor alpha4beta2
0
Quinpirole
20OP60125T
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
67287-49-4
Reserpine
8B1QWR724A
Oxidopamine
8HW4YBZ748
1-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine
9J9974WIBA
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
220-228Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.