Bortezomib and Immune Globulin Have Limited Effects on Donor-Specific HLA Antibodies in Haploidentical Cord Blood Stem Cell Transplantation: Detrimental Effect of Persistent Haploidentical Donor-Specific HLA Antibodies.
Adult
Aged
Allografts
Bortezomib
/ administration & dosage
Cord Blood Stem Cell Transplantation
Female
HLA Antigens
/ blood
Humans
Immunoglobulins, Intravenous
/ administration & dosage
Isoantibodies
/ blood
Male
Middle Aged
Multiple Myeloma
/ blood
Retrospective Studies
Transplantation Conditioning
Autologous stem cell transplantation
Endpoint
Immune profiling
Minimal residual disease
Multiple myeloma
Journal
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
ISSN: 1523-6536
Titre abrégé: Biol Blood Marrow Transplant
Pays: United States
ID NLM: 9600628
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
27
04
2018
accepted:
19
10
2018
entrez:
22
1
2019
pubmed:
22
1
2019
medline:
25
12
2019
Statut:
ppublish
Résumé
Donor-specific HLA antibodies (DSAs) have been associated with an increased risk of graft failure. To decrease DSA levels and reduce the risk of graft failure in haploidentical cord blood transplantation recipients, we studied the effect of bortezomib (BTZ) and i.v. immune globulin (IVIG) pretransplantation. Between 2012 and 2016, 14 patients with a DSA level >2000 mean fluorescence intensity (MFI) to 1 or more mismatched HLA alleles of haploidentical donors, cord blood donors, or both were treated with BTZ and IVIG. Fourteen patients received a median of 4 doses (range, 2 to 8 doses) of BTZ 1.3 mg/m
Identifiants
pubmed: 30661542
pii: S1083-8791(18)30651-7
doi: 10.1016/j.bbmt.2018.10.018
pii:
doi:
Substances chimiques
HLA Antigens
0
Immunoglobulins, Intravenous
0
Isoantibodies
0
Bortezomib
69G8BD63PP
Types de publication
Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e60-e64Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR002384
Pays : United States
Informations de copyright
Copyright © 2018. Published by Elsevier Inc.