Directed Non-targeted Mass Spectrometry and Chemical Networking for Discovery of Eicosanoids and Related Oxylipins.

Aged Chromatography, High Pressure Liquid Eicosanoids / analysis Female Humans Inflammation / metabolism Male Middle Aged Oxylipins / analysis Tandem Mass Spectrometry
GNPS directed non-targeted metabolomics eicosanoids mass spectrometry oxylipins spectral networking

Journal

Cell chemical biology
ISSN: 2451-9448
Titre abrégé: Cell Chem Biol
Pays: United States
ID NLM: 101676030

Informations de publication

Date de publication:
21 03 2019
Historique:
received: 06 06 2018
revised: 04 09 2018
accepted: 26 11 2018
pubmed: 22 1 2019
medline: 31 12 2019
entrez: 22 1 2019
Statut: ppublish

Résumé

Eicosanoids and related oxylipins are critical, small bioactive mediators of human physiology and inflammation. While ∼1,100 distinct species have been predicted to exist, to date, less than 150 of these molecules have been measured in humans, limiting our understanding of their role in human biology. Using a directed non-targeted mass spectrometry approach in conjunction with chemical networking of spectral fragmentation patterns, we find over 500 discrete chemical signals highly consistent with known and putative eicosanoids and related oxylipins in human plasma including 46 putative molecules not previously described. In plasma samples from 1,500 individuals, we find members of this expanded oxylipin library hold close association with markers of inflammation, as well as clinical characteristics linked with inflammation, including advancing age and obesity. These experimental and computational approaches enable discovery of new chemical entities and will shed important insight into the role of bioactive molecules in human health and disease.

Identifiants

DOI: 10.1016/j.chembiol.2018.11.015 PMID: 30661990 PMC: PMC6636917
pubmed: 30661990
pii: S2451-9456(18)30437-9
doi: 10.1016/j.chembiol.2018.11.015
pmc: PMC6636917
mid: NIHMS1518389
pii:
doi:

Substances chimiques

Eicosanoids 0
Oxylipins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

433-442.e4

Subventions

Organisme : NIEHS NIH HHS
ID : R01 ES027595
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201500001C
Pays : United States
Organisme : NIA NIH HHS
ID : R03 AG053287
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK105961
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134168
Pays : United States
Organisme : NIH HHS
ID : S10 OD020025
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK063491
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201500001I
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL143227
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK112940
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA199376
Pays : United States
Organisme : NIDDK NIH HHS
ID : K01 DK116917
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134811
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM069338
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM020501
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL136852
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI135972
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC25195
Pays : United States

Informations de copyright

Copyright © 2018 Elsevier Ltd. All rights reserved.

Références

Anal Biochem. 2005 Nov 1;346(1):1-42
pubmed: 15961057
Nat Rev Immunol. 2015 Aug;15(8):511-23
pubmed: 26139350
J Clin Invest. 2001 Jul;108(1):15-23
pubmed: 11435451
J Mass Spectrom. 2012 Feb;47(2):226-36
pubmed: 22359333
J Am Soc Mass Spectrom. 1996 Feb;7(2):140-9
pubmed: 24203234
J Am Soc Mass Spectrom. 2008 Apr;19(4):569-85
pubmed: 18296063
Nucleic Acids Res. 2018 Jan 4;46(D1):D608-D617
pubmed: 29140435
Nucleic Acids Res. 2014 Jul;42(Web Server issue):W94-9
pubmed: 24895432
Hypertens Res. 2002 Jan;25(1):91-8
pubmed: 11924732
Nat Biotechnol. 2016 Aug 9;34(8):828-837
pubmed: 27504778
Anal Biochem. 2013 Feb 15;433(2):181-8
pubmed: 23103340
J Chromatogr A. 2014 Sep 12;1359:60-9
pubmed: 25074422
Lancet. 1981 Mar 21;1(8221):653-7
pubmed: 6110874
J Mammary Gland Biol Neoplasia. 2013 Dec;18(3-4):291-307
pubmed: 24170420
J Cheminform. 2016 Jan 29;8:3
pubmed: 26834843
Cell Metab. 2016 May 10;23(5):930-44
pubmed: 27133131
Anal Chem. 2017 Feb 7;89(3):1399-1404
pubmed: 28208263
Nat Biotechnol. 2012 Oct;30(10):918-20
pubmed: 23051804
N Engl J Med. 2011 Nov 10;365(19):1812-23
pubmed: 22070478
Science. 2001 Nov 30;294(5548):1871-5
pubmed: 11729303
Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):27-36
pubmed: 21864702
Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2265-74
pubmed: 17209008
Clin Microbiol Rev. 2003 Jul;16(3):517-33
pubmed: 12857780
Nat Med. 1999 Jun;5(6):698-701
pubmed: 10371510
Lancet. 2001 Jun 16;357(9272):1946-7
pubmed: 11425419
Nature. 1999 Jun 24;399(6738):789-93
pubmed: 10391245
JAMA. 1979 May 11;241(19):2035-8
pubmed: 430798
Biopreserv Biobank. 2016 Apr;14(2):107-13
pubmed: 26886177
Trends Mol Med. 2008 Oct;14(10):461-9
pubmed: 18774339
Nutrients. 2010 Mar;2(3):355-74
pubmed: 22254027
Curr Top Med Chem. 2007;7(3):311-40
pubmed: 17305573
Adv Biol Regul. 2014 Jan;54:99-110
pubmed: 24113376
Biochim Biophys Acta. 2015 Apr;1851(4):377-82
pubmed: 25218301
J Am Soc Mass Spectrom. 1995 Dec;6(12):1190-201
pubmed: 24214070
Exp Biol Med (Maywood). 2008 Jun;233(6):674-88
pubmed: 18408140
Cell. 2016 Dec 15;167(7):1897
pubmed: 27984736
Crit Care Med. 2017 Jan;45(1):58-68
pubmed: 27632672
Biochim Biophys Acta. 2015 Apr;1851(4):456-68
pubmed: 25486530
Prostaglandins Other Lipid Mediat. 2014 Oct;113-115:45-51
pubmed: 25151892
J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 1;964:79-88
pubmed: 24742369
Nat Immunol. 2001 Jul;2(7):612-9
pubmed: 11429545
J Lipid Res. 2009 Jun;50(6):1015-38
pubmed: 19244215
J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 1;964:50-64
pubmed: 24685838
Circulation. 2000 Oct 31;102(18):2165-8
pubmed: 11056086
J Biol Chem. 2009 May 29;284(22):14744-59
pubmed: 19324874
Biochem Biophys Res Commun. 2018 Oct 7;504(3):553-561
pubmed: 29524409
J Lipid Res. 2011 Apr;52(4):850-9
pubmed: 21317107
Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):E1743-52
pubmed: 22586093
J Mass Spectrom. 1997 Aug;32(8):888-96
pubmed: 9269087
Prostaglandins Leukot Essent Fatty Acids. 2007 Nov-Dec;77(5-6):363-6
pubmed: 18036802
J Am Soc Mass Spectrom. 2002 Oct;13(10):1227-34
pubmed: 12387329
Biochem Biophys Res Commun. 2014 Apr 4;446(2):633-7
pubmed: 24631907
Expert Opin Drug Metab Toxicol. 2008 Feb;4(2):165-74
pubmed: 18248310
J Exp Med. 2000 Aug 7;192(3):421-32
pubmed: 10934230
J Lipid Res. 2010 Nov;51(11):3299-305
pubmed: 20671299
BMC Bioinformatics. 2010 Jul 23;11:395
pubmed: 20650010
Nature. 1997 Jun 5;387(6633):620-4
pubmed: 9177352
J Lipid Res. 2009 Apr;50 Suppl:S9-14
pubmed: 19098281
Clin Chem. 2014 Feb;60(2):399-412
pubmed: 24305685
Sci Rep. 2017 Feb 03;7:41905
pubmed: 28157230

Auteurs

Jeramie D Watrous (JD)

Departments of Medicine and Pharmacology, University of California, San Diego, CA, USA.

Teemu J Niiranen (TJ)

Department of Medicine, Turku University Hospital and University of Turku, Turku, Finland; Department of Public Health Solutions, National Institute for Health and Welfare, Turku, Finland.

Kim A Lagerborg (KA)

Departments of Medicine and Pharmacology, University of California, San Diego, CA, USA.

Mir Henglin (M)

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Yong-Jiang Xu (YJ)

Departments of Medicine and Pharmacology, University of California, San Diego, CA, USA.

Jian Rong (J)

Framingham Heart Study, Framingham, MA, USA; Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.

Sonia Sharma (S)

La Jolla Institute for Immunology, La Jolla, CA, USA.

Ramachandran S Vasan (RS)

Framingham Heart Study, Framingham, MA, USA; Department of Epidemiology, School of Public Health, Boston University, Boston, MA, USA; Sections of Preventive Medicine and Cardiovascular Medicine, School of Medicine, Boston University, Boston, MA, USA.

Martin G Larson (MG)

Framingham Heart Study, Framingham, MA, USA; Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.

Aaron Armando (A)

Departments of Chemistry and Biochemistry and Pharmacology, University of California, San Diego, CA, USA.

Samia Mora (S)

Center for Lipid Metabolomics, Divisions of Preventive and Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Oswald Quehenberger (O)

Departments of Medicine and Pharmacology, University of California, San Diego, CA, USA.

Edward A Dennis (EA)

Departments of Chemistry and Biochemistry and Pharmacology, University of California, San Diego, CA, USA.

Susan Cheng (S)

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Framingham Heart Study, Framingham, MA, USA; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address: susan.cheng@cshs.org.

Mohit Jain (M)

Departments of Medicine and Pharmacology, University of California, San Diego, CA, USA. Electronic address: mjain@ucsd.edu.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Directed Non-targeted Mass Spectrometry and...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Chromatographie en phase liquide à haute performance › Directed Non-targeted Mass Spectrometry and...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Éicosanoïdes › Directed Non-targeted Mass Spectrometry and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Directed Non-targeted Mass Spectrometry and...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Directed Non-targeted Mass Spectrometry and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Directed Non-targeted Mass Spectrometry and...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Oxylipines › Directed Non-targeted Mass Spectrometry and...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › Directed Non-targeted Mass Spectrometry and...