Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects.
Adipose Tissue
/ chemistry
Anthropometry
Arm
/ anatomy & histology
Biological Specimen Banks
Body Fat Distribution
Body Mass Index
Body Weight
Electric Impedance
Endocrine Glands
/ chemistry
Female
Gene Expression Profiling
Gene Expression Regulation
Genetic Heterogeneity
Genetic Loci
Genome-Wide Association Study
Humans
Leg
/ anatomy & histology
Male
Obesity
/ genetics
Polymorphism, Single Nucleotide
Sex Factors
Torso
/ anatomy & histology
United Kingdom
Waist-Hip Ratio
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
21 01 2019
21 01 2019
Historique:
received:
05
07
2018
accepted:
11
12
2018
entrez:
22
1
2019
pubmed:
22
1
2019
medline:
6
2
2019
Statut:
epublish
Résumé
Body mass and body fat composition are of clinical interest due to their links to cardiovascular- and metabolic diseases. Fat stored in the trunk has been suggested to be more pathogenic compared to fat stored in other compartments. In this study, we perform genome-wide association studies (GWAS) for the proportion of body fat distributed to the arms, legs and trunk estimated from segmental bio-electrical impedance analysis (sBIA) for 362,499 individuals from the UK Biobank. 98 independent associations with body fat distribution are identified, 29 that have not previously been associated with anthropometric traits. A high degree of sex-heterogeneity is observed and the effects of 37 associated variants are stronger in females compared to males. Our findings also implicate that body fat distribution in females involves mesenchyme derived tissues and cell types, female endocrine tissues as well as extracellular matrix maintenance and remodeling.
Identifiants
pubmed: 30664634
doi: 10.1038/s41467-018-08000-4
pii: 10.1038/s41467-018-08000-4
pmc: PMC6341104
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
339Subventions
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
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