Transient receptor potential channels in cardiac health and disease.
Action Potentials
Animals
Cardiovascular Agents
/ therapeutic use
Fibroblasts
/ drug effects
Heart Diseases
/ drug therapy
Humans
Molecular Targeted Therapy
Myocytes, Cardiac
/ drug effects
Purkinje Fibers
/ drug effects
Signal Transduction
Sinoatrial Node
/ drug effects
Transient Receptor Potential Channels
/ drug effects
Journal
Nature reviews. Cardiology
ISSN: 1759-5010
Titre abrégé: Nat Rev Cardiol
Pays: England
ID NLM: 101500075
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
pubmed:
22
1
2019
medline:
21
1
2020
entrez:
22
1
2019
Statut:
ppublish
Résumé
Transient receptor potential (TRP) channels are nonselective cationic channels that are generally Ca
Identifiants
pubmed: 30664669
doi: 10.1038/s41569-018-0145-2
pii: 10.1038/s41569-018-0145-2
doi:
Substances chimiques
Cardiovascular Agents
0
Transient Receptor Potential Channels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
344-360Références
Montell, C. & Rubin, G. M. Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction. Neuron 2, 1313–1323 (1989).
doi: 10.1016/0896-6273(89)90069-X
pubmed: 2516726
Madej, M. G. & Ziegler, C. M. Dawning of a new era in TRP channel structural biology by cryo-electron microscopy. Pflugers Arch. 470, 213–225 (2018).
doi: 10.1007/s00424-018-2107-2
pubmed: 29344776
Guo, J. et al. Structures of the calcium-activated, non-selective cation channel TRPM4. Nature 552, 205–209 (2017).
pubmed: 29211714
pmcid: 5901961
doi: 10.1038/nature24997
Yin, Y. et al. Structure of the cold- and menthol-sensing ion channel TRPM8. Science 359, 237–241 (2018).
doi: 10.1126/science.aan4325
pubmed: 29217583
Benemei, S., Patacchini, R., Trevisani, M. & Geppetti, P. TRP channels. Curr. Opin. Pharmacol. 22, 18–23 (2015).
doi: 10.1016/j.coph.2015.02.006
pubmed: 25725213
Yue, Z. et al. Role of TRP channels in the cardiovascular system. Am. J. Physiol. Heart Circ. Physiol. 308, H157–H182 (2015).
doi: 10.1152/ajpheart.00457.2014
pubmed: 25416190
Hofmann, L. et al. The S4–S5 linker — gearbox of TRP channel gating. Cell Calcium 67, 156–165 (2017).
doi: 10.1016/j.ceca.2017.04.002
pubmed: 28416203
Clapham, D. E. TRP channels as cellular sensors. Nature 426, 517–524 (2003).
doi: 10.1038/nature02196
pubmed: 14654832
Avila-Medina, J. et al. The complex role of store operated calcium entry pathways and related proteins in the function of cardiac, skeletal and vascular smooth muscle cells. Front. Physiol. 9, 257 (2018).
pubmed: 29618985
pmcid: 5872157
doi: 10.3389/fphys.2018.00257
Vennekens, R. Recent insights on the role of TRP channels in cardiac muscle. Curr. Opin. Physiol. 1, 172–184 (2018).
doi: 10.1016/j.cophys.2017.12.001
Runnels, L. W. TRPM6 and TRPM7: a Mul-TRP-PLIK-cation of channel functions. Curr. Pharm. Biotechnol. 12, 42–53 (2011).
pubmed: 20932259
pmcid: 3514077
doi: 10.2174/138920111793937880
Du, J., Xie, J. & Yue, L. Intracellular calcium activates TRPM2 and its alternative spliced isoforms. Proc. Natl Acad. Sci. USA 106, 7239–7244 (2009).
doi: 10.1073/pnas.0811725106
pubmed: 19372375
pmcid: 2678461
Guinamard, R., Salle, L. & Simard, C. The non-selective monovalent cationic channels TRPM4 and TRPM5. Adv. Exp. Med. Biol. 704, 147–171 (2011).
doi: 10.1007/978-94-007-0265-3_8
pubmed: 21290294
Lakatta, E. G., Maltsev, V. A. & Vinogradova, T. M. A coupled SYSTEM of intracellular Ca
pubmed: 20203315
pmcid: 2837285
doi: 10.1161/CIRCRESAHA.109.206078
Yanni, J. et al. Changes in ion channel gene expression underlying heart failure-induced sinoatrial node dysfunction. Circ. Heart Fail. 4, 496–508 (2011).
doi: 10.1161/CIRCHEARTFAILURE.110.957647
pubmed: 21565973
Ju, Y. K. et al. Store-operated Ca
doi: 10.1161/CIRCRESAHA.107.152181
pubmed: 17478725
Sabourin, J., Robin, E. & Raddatz, E. A key role of TRPC channels in the regulation of electromechanical activity of the developing heart. Cardiovasc. Res. 92, 226–236 (2011).
doi: 10.1093/cvr/cvr167
pubmed: 21672930
Ju, Y. K. et al. The involvement of TRPC3 channels in sinoatrial arrhythmias. Front. Physiol. 6, 86 (2015).
pubmed: 25859221
pmcid: 4373262
doi: 10.3389/fphys.2015.00086
Hofmann, T. et al. Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397, 259–263 (1999).
doi: 10.1038/16711
pubmed: 9930701
Doleschal, B. et al. TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1. Cardiovasc. Res. 106, 163–173 (2015).
pubmed: 25631581
pmcid: 4362401
doi: 10.1093/cvr/cvv022
Qi, Z. et al. TRPC3 regulates the automaticity of embryonic stem cell-derived cardiomyocytes. Int. J. Cardiol. 203, 169–181 (2016).
doi: 10.1016/j.ijcard.2015.10.018
pubmed: 26512833
Demion, M., Bois, P., Launay, P. & Guinamard, R. TRPM4, a Ca
doi: 10.1016/j.cardiores.2006.11.023
pubmed: 17188667
Sasse, P. et al. Intracellular Ca
pubmed: 17664344
pmcid: 2151640
doi: 10.1085/jgp.200609575
Guo, J., Ono, K. & Noma, A. Monovalent cation conductance of the sustained inward current in rabbit sinoatrial node cells. Pflugers Arch. 433, 209–211 (1996).
doi: 10.1007/s004240050269
pubmed: 9019725
Guinamard, R., Hof, T. & Del Negro, C. A. The TRPM4 channel inhibitor 9-phenanthrol. Br. J. Pharmacol. 171, 1600–1613 (2014).
pubmed: 24433510
pmcid: 3966741
doi: 10.1111/bph.12582
Hof, T., Simard, C., Rouet, R., Salle, L. & Guinamard, R. Implication of the TRPM4 nonselective cation channel in mammalian sinus rhythm. Heart Rhythm 10, 1683–1689 (2013).
doi: 10.1016/j.hrthm.2013.08.014
pubmed: 23954346
Hu, Y. et al. Uncovering the arrhythmogenic potential of TRPM4 activation in atrial-derived HL-1 cells using novel recording and numerical approaches. Cardiovasc. Res. 113, 1243–1255 (2017).
doi: 10.1093/cvr/cvx117
pubmed: 28898995
DiFrancesco, D. The role of the funny current in pacemaker activity. Circ. Res. 106, 434–446 (2010).
pubmed: 20167941
doi: 10.1161/CIRCRESAHA.109.208041
Sah, R. et al. Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity. Proc. Natl Acad. Sci. USA 110, E3037–E3046 (2013).
doi: 10.1073/pnas.1311865110
pubmed: 23878236
pmcid: 3740880
Zhang, Y. H. et al. Functional transient receptor potential canonical type 1 channels in human atrial myocytes. Pflugers Arch. 465, 1439–1449 (2013).
pubmed: 23686296
doi: 10.1007/s00424-013-1291-3
Guinamard, R. et al. Functional characterization of a Ca
pubmed: 15121803
pmcid: 1664929
doi: 10.1113/jphysiol.2004.063974
Zhang, Y. H. et al. Evidence for functional expression of TRPM7 channels in human atrial myocytes. Basic Res. Cardiol. 107, 282 (2012).
pubmed: 22802050
pmcid: 3442166
doi: 10.1007/s00395-012-0282-4
Macianskiene, R., Almanaityte, M., Jekabsone, A. & Mubagwa, K. Modulation of human cardiac TRPM7 current by extracellular acidic pH depends upon extracellular concentrations of divalent cations. PLOS ONE 12, e0170923 (2017).
pubmed: 28129376
pmcid: 5271359
doi: 10.1371/journal.pone.0170923
Simard, C., Hof, T., Keddache, Z., Launay, P. & Guinamard, R. The TRPM4 non-selective cation channel contributes to the mammalian atrial action potential. J. Mol. Cell. Cardiol. 59, 11–19 (2013).
pubmed: 23416167
doi: 10.1016/j.yjmcc.2013.01.019
Demion, M. et al. Trpm4 gene invalidation leads to cardiac hypertrophy and electrophysiological alterations. PLOS ONE 9, e115256 (2014).
pubmed: 25531103
pmcid: 4274076
doi: 10.1371/journal.pone.0115256
Guinamard, R. et al. TRPM4 in cardiac electrical activity. Cardiovasc. Res. 108, 21–30 (2015).
pubmed: 26272755
doi: 10.1093/cvr/cvv213
Odnoshivkina, U. G. et al. β2-adrenoceptor agonist-evoked reactive oxygen species generation in mouse atria: implication in delayed inotropic effect. Eur. J. Pharmacol. 765, 140–153 (2015).
doi: 10.1016/j.ejphar.2015.08.020
pubmed: 26297975
Chevalier, M. et al. Transcriptomic analyses of murine ventricular cardiomyocytes. Sci. Data 5, 180170 (2018).
pubmed: 30129933
pmcid: 6103258
doi: 10.1038/sdata.2018.170
Pazienza, V. et al. The TRPA1 channel is a cardiac target of mIGF-1/SIRT1 signaling. Am. J. Physiol. Heart Circ. Physiol. 307, H939–H944 (2014).
doi: 10.1152/ajpheart.00150.2014
pubmed: 25108014
Lu, Y., Piplani, H., McAllister, S. L., Hurt, C. M. & Gross, E. R. Transient receptor potential ankyrin 1 activation within the cardiac myocyte limits ischemia-reperfusion injury in rodents. Anesthesiology 125, 1171–1180 (2016).
pubmed: 27748654
doi: 10.1097/ALN.0000000000001377
Andrei, S. R., Sinharoy, P., Bratz, I. N. & Damron, D. S. TRPA1 is functionally co-expressed with TRPV1 in cardiac muscle: co-localization at Z-discs, costameres and intercalated discs. Channels 10, 395–409 (2016).
pubmed: 27144598
pmcid: 4988441
doi: 10.1080/19336950.2016.1185579
Bodkin, J. V. et al. Investigating the potential role of TRPA1 in locomotion and cardiovascular control during hypertension. Pharmacol. Res. Perspect. 2, e00052 (2014).
pubmed: 25505598
pmcid: 4186440
doi: 10.1002/prp2.52
Andrei, S. R. et al. TRPA1 ion channel stimulation enhances cardiomyocyte contractile function via a CaMKII-dependent pathway. Channels 11, 587–603 (2017).
pubmed: 28792844
pmcid: 5786180
doi: 10.1080/19336950.2017.1365206
Camacho Londono, J. E. et al. A background Ca
pubmed: 26069213
pmcid: 4554959
doi: 10.1093/eurheartj/ehv250
Miller, B. A. et al. The second member of transient receptor potential-melastatin channel family protects hearts from ischemia-reperfusion injury. Am. J. Physiol. Heart Circ. Physiol. 304, H1010–H1022 (2013).
pubmed: 23376831
pmcid: 3625898
doi: 10.1152/ajpheart.00906.2012
Hoffman, N. E. et al. Ca
pubmed: 25576627
pmcid: 4360055
doi: 10.1152/ajpheart.00720.2014
Hof, T. et al. TRPM4 non-selective cation channels influence action potentials in rabbit Purkinje fibres. J. Physiol. 594, 295–306 (2016).
pubmed: 26548780
doi: 10.1113/JP271347
Guinamard, R., Demion, M., Magaud, C., Potreau, D. & Bois, P. Functional expression of the TRPM4 cationic current in ventricular cardiomyocytes from spontaneously hypertensive rats. Hypertension 48, 587–594 (2006).
pubmed: 16966582
doi: 10.1161/01.HYP.0000237864.65019.a5
Guinamard, R., Rahmati, M., Lenfant, J. & Bois, P. Characterization of a Ca
pubmed: 12172638
doi: 10.1007/s00232-001-0180-4
Mathar, I. et al. Increased beta-adrenergic inotropy in ventricular myocardium from Trpm4
pubmed: 24226423
doi: 10.1161/CIRCRESAHA.114.302835
Gueffier, M. et al. The TRPM4 channel is functionally important for the beneficial cardiac remodeling induced by endurance training. J. Muscle Res. Cell. Motil. 38, 3–16 (2017).
pubmed: 28224334
doi: 10.1007/s10974-017-9466-8
Kecskes, M. et al. The Ca
pubmed: 26043922
pmcid: 4456993
doi: 10.1007/s00395-015-0501-x
Saito, Y. et al. TRPM4 mutation in patients with ventricular noncompaction and cardiac conduction disease. Circ. Genom. Precis. Med. 11, e002103 (2018).
pubmed: 29748318
doi: 10.1161/CIRCGEN.118.002103
Gwanyanya, A., Sipido, K. R., Vereecke, J. & Mubagwa, K. ATP and PIP
pubmed: 16707555
doi: 10.1152/ajpcell.00074.2006
Sah, R. et al. Timing of myocardial Trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization. Circulation 128, 101–114 (2013).
pubmed: 23734001
doi: 10.1161/CIRCULATIONAHA.112.000768
Rubinstein, J. et al. Novel role of transient receptor potential vanilloid 2 in the regulation of cardiac performance. Am. J. Physiol. Heart Circ. Physiol. 306, H574–H584 (2014).
pubmed: 24322617
doi: 10.1152/ajpheart.00854.2013
Aguettaz, E. et al. Axial stretch-dependent cation entry in dystrophic cardiomyopathy: involvement of several TRPs channels. Cell Calcium 59, 145–155 (2016).
pubmed: 26803937
pmcid: 4844790
doi: 10.1016/j.ceca.2016.01.001
Aguettaz, E., Bois, P., Cognard, C. & Sebille, S. Stretch-activated TRPV2 channels: role in mediating cardiopathies. Prog. Biophys. Mol. Biol. 130, 273–280 (2017).
pubmed: 28546113
doi: 10.1016/j.pbiomolbio.2017.05.007
Katanosaka, Y. et al. TRPV2 is critical for the maintenance of cardiac structure and function in mice. Nat. Commun. 5, 3932 (2014).
pubmed: 24874017
doi: 10.1038/ncomms4932
Zhao, Y. et al. Unusual localization and translocation of TRPV4 protein in cultured ventricular myocytes of the neonatal rat. Eur. J. Histochem. 56, e32 (2012).
pubmed: 23027348
pmcid: 3493978
doi: 10.4081/ejh.2012.e32
Hu, L., Ma, J., Zhang, P. & Zheng, J. Extracellular hypotonicity induces disturbance of sodium currents in rat ventricular myocytes. Physiol. Res. 58, 807–815 (2009).
doi: 10.33549/physiolres.931692
pubmed: 19093733
Li, J. et al. Role of transient receptor potential vanilloid 4 in the effect of osmotic pressure on myocardial contractility in rat. Sheng Li Xue Bao 60, 181–188 (2008).
pubmed: 18425304
Heckel, E. et al. Oscillatory flow modulates mechanosensitive klf2a expression through trpv4 and trpp2 during heart valve development. Curr. Biol. 25, 1354–1361 (2015).
doi: 10.1016/j.cub.2015.03.038
pubmed: 25959969
Fick, G. M., Johnson, A. M., Hammond, W. S. & Gabow, P. A. Causes of death in autosomal dominant polycystic kidney disease. J. Am. Soc. Nephrol. 5, 2048–2056 (1995).
doi: 10.1681/ASN.V5122048
pubmed: 7579053
Paavola, J. et al. Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy. J. Mol. Cell. Cardiol. 58, 199–208 (2013).
pubmed: 23376035
pmcid: 3636149
doi: 10.1016/j.yjmcc.2013.01.015
Volk, T., Schwoerer, A. P., Thiessen, S., Schultz, J. H. & Ehmke, H. A polycystin-2-like large conductance cation channel in rat left ventricular myocytes. Cardiovasc. Res. 58, 76–88 (2003).
doi: 10.1016/S0008-6363(02)00858-1
pubmed: 12667948
Anyatonwu, G. I., Estrada, M., Tian, X., Somlo, S. & Ehrlich, B. E. Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2. Proc. Natl Acad. Sci. USA 104, 6454–6459 (2007).
doi: 10.1073/pnas.0610324104
pubmed: 17404231
pmcid: 1851053
Kuo, I. Y. et al. Decreased polycystin 2 expression alters calcium-contraction coupling and changes beta-adrenergic signaling pathways. Proc. Natl Acad. Sci. USA 111, 16604–16609 (2014).
doi: 10.1073/pnas.1415933111
pubmed: 25368166
pmcid: 4246301
Haissaguerre, M., Vigmond, E., Stuyvers, B., Hocini, M. & Bernus, O. Ventricular arrhythmias and the His-Purkinje system. Nat. Rev. Cardiol. 13, 155–166 (2016).
doi: 10.1038/nrcardio.2015.193
pubmed: 26727298
Hirose, M., Stuyvers, B. D., Dun, W., ter Keurs, H. E. & Boyden, P. A. Function of Ca
pubmed: 19753099
pmcid: 2727694
doi: 10.1161/CIRCEP.107.758110
Huang, H. et al. TRPC1 expression and distribution in rat hearts. Eur. J. Histochem. 53, e26 (2009).
pubmed: 22073358
pmcid: 3167335
doi: 10.4081/ejh.2009.e26
Liu, H. et al. Gain-of-function mutations in TRPM4 cause autosomal dominant isolated cardiac conduction disease. Circ. Cardiovasc. Genet. 3, 374–385 (2010).
doi: 10.1161/CIRCGENETICS.109.930867
pubmed: 20562447
Kruse, M. et al. Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I. J. Clin. Invest. 119, 2737–2744 (2009).
pubmed: 19726882
pmcid: 2735920
doi: 10.1172/JCI38292
Lighthouse, J. K. & Small, E. M. Transcriptional control of cardiac fibroblast plasticity. J. Mol. Cell. Cardiol. 91, 52–60 (2016).
doi: 10.1016/j.yjmcc.2015.12.016
pubmed: 26721596
Thodeti, C. K., Paruchuri, S. & Meszaros, J. G. A. TRP to cardiac fibroblast differentiation. Channels 7, 211–214 (2013).
pubmed: 23511028
pmcid: 3710348
doi: 10.4161/chan.24328
Hinz, B. Formation and function of the myofibroblast during tissue repair. J. Invest. Dermatol. 127, 526–537 (2007).
doi: 10.1038/sj.jid.5700613
pubmed: 17299435
Davis, J., Burr, A. R., Davis, G. F., Birnbaumer, L. & Molkentin, J. D. A. TRPC6-dependent pathway for myofibroblast transdifferentiation and wound healing in vivo. Dev. Cell 23, 705–715 (2012).
pubmed: 23022034
pmcid: 3505601
doi: 10.1016/j.devcel.2012.08.017
Nattel, S. & Dobrev, D. The multidimensional role of calcium in atrial fibrillation pathophysiology: mechanistic insights and therapeutic opportunities. Eur. Heart J. 33, 1870–1877 (2012).
doi: 10.1093/eurheartj/ehs079
pubmed: 22507975
Nattel, S. & Dobrev, D. Electrophysiological and molecular mechanisms of paroxysmal atrial fibrillation. Nat. Rev. Cardiol. 13, 575–590 (2016).
doi: 10.1038/nrcardio.2016.118
pubmed: 27489190
Macianskiene, R., Martisiene, I., Zablockaite, D. & Gendviliene, V. Characterization of Mg
pubmed: 22891975
pmcid: 3431234
doi: 10.1186/1423-0127-19-75
Ohba, T. et al. Upregulation of TRPC1 in the development of cardiac hypertrophy. J. Mol. Cell. Cardiol. 42, 498–507 (2007).
doi: 10.1016/j.yjmcc.2006.10.020
pubmed: 17174323
Han, J. W. et al. Resistance to pathologic cardiac hypertrophy and reduced expression of Ca
doi: 10.1007/s11010-016-2784-0
pubmed: 27522668
Seo, K. et al. Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy. Proc. Natl Acad. Sci. USA 111, 1551–1556 (2014).
doi: 10.1073/pnas.1308963111
pubmed: 24453217
pmcid: 3910575
Swaminathan, P. D., Purohit, A., Hund, T. J. & Anderson, M. E. Calmodulin-dependent protein kinase II: linking heart failure and arrhythmias. Circ. Res. 110, 1661–1677 (2012).
pubmed: 22679140
pmcid: 3789535
doi: 10.1161/CIRCRESAHA.111.243956
Bush, E. W. et al. Canonical transient receptor potential channels promote cardiomyocyte hypertrophy through activation of calcineurin signaling. J. Biol. Chem. 281, 33487–33496 (2006).
doi: 10.1074/jbc.M605536200
pubmed: 16950785
Oguri, G. et al. Effects of methylglyoxal on human cardiac fibroblast: roles of transient receptor potential ankyrin 1 (TRPA1) channels. Am. J. Physiol. Heart Circ. Physiol. 307, H1339–H1352 (2014).
doi: 10.1152/ajpheart.01021.2013
pubmed: 25172898
Adapala, R. K. et al. TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals. J. Mol. Cell. Cardiol. 54, 45–52 (2013).
doi: 10.1016/j.yjmcc.2012.10.016
pubmed: 23142541
Wu, X., Eder, P., Chang, B. & Molkentin, J. D. TRPC channels are necessary mediators of pathologic cardiac hypertrophy. Proc. Natl Acad. Sci. USA 107, 7000–7005 (2010).
doi: 10.1073/pnas.1001825107
Goel, M., Zuo, C. D., Sinkins, W. G. & Schilling, W. P. TRPC3 channels colocalize with Na
doi: 10.1152/ajpheart.00785.2006
pubmed: 17012351
Kitajima, N. et al. TRPC3-mediated Ca
doi: 10.1016/j.bbrc.2011.04.124
pubmed: 21565173
Wagner, S. et al. NADPH oxidase 2 mediates angiotensin II-dependent cellular arrhythmias via PKA and CaMKII. J. Mol. Cell. Cardiol. 75, 206–215 (2014).
doi: 10.1016/j.yjmcc.2014.07.011
pubmed: 25073061
Morine, K. J. et al. Endoglin selectively modulates transient receptor potential channel expression in left and right heart failure. Cardiovasc. Pathol. 25, 478–482 (2016).
pubmed: 27614169
pmcid: 5443561
doi: 10.1016/j.carpath.2016.08.004
Ohba, T. et al. Regulatory role of neuron-restrictive silencing factor in expression of TRPC1. Biochem. Biophys. Res. Commun. 351, 764–770 (2006).
doi: 10.1016/j.bbrc.2006.10.107
pubmed: 17084381
Nakayama, H., Wilkin, B. J., Bodi, I. & Molkentin, J. D. Calcineurin-dependent cardiomyopathy is activated by TRPC in the adult mouse heart. FASEB J. 20, 1660–1670 (2006).
pubmed: 16873889
doi: 10.1096/fj.05-5560com
Brenner, J. S. & Dolmetsch, R. E. TrpC3 regulates hypertrophy-associated gene expression without affecting myocyte beating or cell size. PLOS ONE 2, e802 (2007).
pubmed: 17726532
pmcid: 1950081
doi: 10.1371/journal.pone.0000802
Koitabashi, N. et al. Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation: novel mechanism of cardiac stress modulation by PDE5 inhibition. J. Mol. Cell. Cardiol. 48, 713–724 (2010).
doi: 10.1016/j.yjmcc.2009.11.015
pubmed: 19961855
Onohara, N. et al. TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy. EMBO J. 25, 5305–5316 (2006).
pubmed: 17082763
pmcid: 1636614
doi: 10.1038/sj.emboj.7601417
Kuwahara, K. et al. TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling. J. Clin. Invest. 116, 3114–3126 (2006).
pubmed: 17099778
pmcid: 1635163
doi: 10.1172/JCI27702
Koch, S. E. et al. Transient receptor potential vanilloid 2 function regulates cardiac hypertrophy via stretch-induced activation. J. Hypertens. 35, 602–611 (2017).
doi: 10.1097/HJH.0000000000001213
pubmed: 28009703
Miller, B. A. et al. TRPM2 channels protect against cardiac ischemia-reperfusion injury: role of mitochondria. J. Biol. Chem. 289, 7615–7629 (2014).
pubmed: 24492610
pmcid: 3953274
doi: 10.1074/jbc.M113.533851
Jacobs, G. et al. Enhanced β-adrenergic cardiac reserve in Trpm4
doi: 10.1093/cvr/cvv009
pubmed: 25600961
Wang, J., Takahashi, K., Piao, H., Qu, P. & Naruse, K. 9-Phenanthrol, a TRPM4 inhibitor, protects isolated rat hearts from ischemia-reperfusion injury. PLOS ONE 8, e70587 (2013).
pubmed: 23936231
pmcid: 3723883
doi: 10.1371/journal.pone.0070587
Piao, H. et al. Transient receptor potential melastatin-4 is involved in hypoxia-reoxygenation injury in the cardiomyocytes. PLOS ONE 10, e0121703 (2015).
pubmed: 25836769
pmcid: 4383534
doi: 10.1371/journal.pone.0121703
Simard, C., Salle, L., Rouet, R. & Guinamard, R. Transient receptor potential melastatin 4 inhibitor 9-phenanthrol abolishes arrhythmias induced by hypoxia and re-oxygenation in mouse ventricle. Br. J. Pharmacol. 165, 2354–2364 (2012).
pubmed: 22014185
pmcid: 3413868
doi: 10.1111/j.1476-5381.2011.01715.x
Nilius, B., Prenen, J., Voets, T. & Droogmans, G. Intracellular nucleotides and polyamines inhibit the Ca
doi: 10.1007/s00424-003-1221-x
pubmed: 14758478
Carmeliet, E. Cardiac ionic currents and acute ischemia: from channels to arrhythmias. Physiol. Rev. 79, 917–1017 (1999).
doi: 10.1152/physrev.1999.79.3.917
pubmed: 10390520
Ortega, A. et al. TRPM7 is down-regulated in both left atria and left ventricle of ischaemic cardiomyopathy patients and highly related to changes in ventricular function. ESC Heart Fail. 3, 220–224 (2016).
pubmed: 27818786
pmcid: 5071679
doi: 10.1002/ehf2.12085
Vemula, P., Gautam, B., Abela, G. S. & Wang, D. H. Myocardial ischemia/reperfusion injury: potential of TRPV1 agonists as cardioprotective agents. Cardiovasc. Hematol. Disord. Drug Targets 14, 71–78 (2014).
pubmed: 24304232
doi: 10.2174/1871529X13666131129103759
Randhawa, P. K. & Jaggi, A. S. TRPV1 and TRPV4 channels: potential therapeutic targets for ischemic conditioning-induced cardioprotection. Eur. J. Pharmacol. 746, 180–185 (2015).
doi: 10.1016/j.ejphar.2014.11.010
pubmed: 25449039
Wang, L. & Wang, D. H. TRPV1 gene knockout impairs postischemic recovery in isolated perfused heart in mice. Circulation 112, 3617–3623 (2005).
doi: 10.1161/CIRCULATIONAHA.105.556274
pubmed: 16314376
Huang, W., Rubinstein, J., Prieto, A. R., Thang, L. V. & Wang, D. H. Transient receptor potential vanilloid gene deletion exacerbates inflammation and atypical cardiac remodeling after myocardial infarction. Hypertension 53, 243–250 (2009).
doi: 10.1161/HYPERTENSIONAHA.108.118349
pubmed: 19114647
Dong, Q. et al. Blockage of transient receptor potential vanilloid 4 alleviates myocardial ischemia/reperfusion injury in mice. Sci. Rep. 7, 42678 (2017).
pubmed: 28205608
pmcid: 5311718
doi: 10.1038/srep42678
Syam, N. et al. Variants of transient receptor potential melastatin member 4 in childhood atrioventricular block. J. Am. Heart Assoc. 5, e001625 (2016).
pubmed: 27207958
pmcid: 4889160
doi: 10.1161/JAHA.114.001625
Liu, H. et al. Molecular genetics and functional anomalies in a series of 248 Brugada cases with 11 mutations in the TRPM4 channel. PLOS ONE 8, e54131 (2013).
pubmed: 23382873
pmcid: 3559649
doi: 10.1371/journal.pone.0054131
Hof, T. et al. TRPM4 non-selective cation channel variants in long QT syndrome. BMC Med. Genet. 18, 31 (2017).
pubmed: 28315637
pmcid: 5357330
doi: 10.1186/s12881-017-0397-4
Xian, W. et al. Aberrant deactivation-induced gain of function in TRPM4 mutant is associated with human cardiac conduction block. Cell Rep. 24, 724–731 (2018).
doi: 10.1016/j.celrep.2018.06.034
pubmed: 30021168
Arking, D. E. et al. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Nat. Genet. 46, 826–836 (2014).
pubmed: 24952745
pmcid: 4124521
doi: 10.1038/ng.3014
Eder, P. et al. Phospholipase C-dependent control of cardiac calcium homeostasis involves a TRPC3-NCX1 signaling complex. Cardiovasc. Res. 73, 111–119 (2007).
doi: 10.1016/j.cardiores.2006.10.016
pubmed: 17129578
Kitajima, N. et al. TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling. Sci. Rep. 6, 37001 (2016).
pubmed: 27833156
pmcid: 5105134
doi: 10.1038/srep37001
Yue, Z., Zhang, Y., Xie, J., Jiang, J. & Yue, L. Transient receptor potential (TRP) channels and cardiac fibrosis. Curr. Top. Med. Chem. 13, 270–282 (2013).
pubmed: 23432060
pmcid: 3874073
doi: 10.2174/1568026611313030005
Numaga-Tomita, T. et al. TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis. Sci. Rep. 6, 39383 (2016).
pubmed: 27991560
pmcid: 5171702
doi: 10.1038/srep39383
Oda, S. et al. TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice. Sci. Rep. 7, 7511 (2017).
pubmed: 28790356
pmcid: 5548754
doi: 10.1038/s41598-017-07903-4
Ikeda, K. et al. Roles of transient receptor potential canonical (TRPC) channels and reverse-mode Na
doi: 10.1016/j.ceca.2013.06.005
pubmed: 23827314
Harada, M. et al. Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation. Circulation 126, 2051–2064 (2012).
pubmed: 22992321
pmcid: 3675169
doi: 10.1161/CIRCULATIONAHA.112.121830
Hatano, N., Itoh, Y. & Muraki, K. Cardiac fibroblasts have functional TRPV4 activated by 4α-phorbol 12,13-didecanoate. Life Sci. 85, 808–814 (2009).
doi: 10.1016/j.lfs.2009.10.013
pubmed: 19879881
Du, J. et al. TRPM7-mediated Ca
pubmed: 20075334
pmcid: 2907241
doi: 10.1161/CIRCRESAHA.109.206771
Nakatani, Y. et al. Tranilast prevents atrial remodeling and development of atrial fibrillation in a canine model of atrial tachycardia and left ventricular dysfunction. J. Am. Coll. Cardiol. 61, 582–588 (2013).
doi: 10.1016/j.jacc.2012.11.014
pubmed: 23273396
Guo, J. L. et al. Transient receptor potential melastatin 7 (TRPM7) contributes to H
doi: 10.1254/jphs.13224FP
pubmed: 24871786
Yu, Y. et al. TRPM7 is involved in angiotensin II induced cardiac fibrosis development by mediating calcium and magnesium influx. Cell Calcium 55, 252–260 (2014).
doi: 10.1016/j.ceca.2014.02.019
pubmed: 24680379
Li, S. et al. TRPM7 channels mediate the functional changes in cardiac fibroblasts induced by angiotensin II. Int. J. Mol. Med. 39, 1291–1298 (2017).
doi: 10.3892/ijmm.2017.2943
pubmed: 28393175
Shimauchi, T. et al. TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy. JCI Insight 2, e93358 (2017).
pmcid: 5543921
doi: 10.1172/jci.insight.93358
Ozhathil, L. C. et al. Identification of potent and selective small molecule inhibitors of the cation channel TRPM4. Br. J. Pharmacol. 175, 2504–2519 (2018).
pubmed: 29579323
pmcid: 6002741
doi: 10.1111/bph.14220
Rubaiy, H. N. et al. Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels. J. Biol. Chem. 292, 8158–8173 (2017).
pubmed: 28325835
pmcid: 5437225
doi: 10.1074/jbc.M116.773556
Koch, S. E. et al. Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. J. Mol. Cell. Cardiol. 53, 134–144 (2012).
pubmed: 22561103
pmcid: 3372642
doi: 10.1016/j.yjmcc.2012.04.011
Iwata, Y. et al. Blockade of sarcolemmal TRPV2 accumulation inhibits progression of dilated cardiomyopathy. Cardiovasc. Res. 99, 760–768 (2013).
pubmed: 23786999
doi: 10.1093/cvr/cvt163
Matsumura, T. et al. A pilot study of tranilast for cardiomyopathy of muscular dystrophy. Intern. Med. 57, 311–318 (2018).
pubmed: 29093384
doi: 10.2169/internalmedicine.8651-16
Sheth, K. N. et al. Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Neurol. 15, 1160–1169 (2016).
pubmed: 27567243
doi: 10.1016/S1474-4422(16)30196-X
Okada, T. et al. Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca
pubmed: 10488066
doi: 10.1074/jbc.274.39.27359
Bobkov, Y. V., Corey, E. A. & Ache, B. W. The pore properties of human nociceptor channel TRPA1 evaluated in single channel recordings. Biochim. Biophys. Acta 1808, 1120–1128 (2011).
doi: 10.1016/j.bbamem.2010.12.024
pubmed: 21195050
Gees, M., Colsoul, B. & Nilius, B. The role of transient receptor potential cation channels in Ca
pubmed: 20861159
pmcid: 2944357
doi: 10.1101/cshperspect.a003962
Dominguez-Rodriguez, A. et al. Proarrhythmic effect of sustained EPAC activation on TRPC3/4 in rat ventricular cardiomyocytes. J. Mol. Cell. Cardiol. 87, 74–78 (2015).
pubmed: 26219954
doi: 10.1016/j.yjmcc.2015.07.002
Wang, Y., Chen, M. S., Liu, H. C., Xiao, J. H. & Wang, J. L. The relationship between frequency dependence of action potential duration and the expression of TRPC3 in rabbit ventricular myocardium. Cell Physiol. Biochem. 33, 646–656 (2014).
doi: 10.1159/000358641
pubmed: 24642929
Dyachenko, V., Husse, B., Rueckschloss, U. & Isenberg, G. Mechanical deformation of ventricular myocytes modulates both TRPC6 and K
doi: 10.1016/j.ceca.2008.06.003
pubmed: 18635261
Xie, J. et al. Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart. Nat. Commun. 3, 1238 (2012).
pubmed: 23212367
doi: 10.1038/ncomms2240
Demir, T. et al. Evaluation of TRPM (transient receptor potential melastatin) genes expressions in myocardial ischemia and reperfusion. Mol. Biol. Rep. 41, 2845–2849 (2014).
doi: 10.1007/s11033-014-3139-0
pubmed: 24445530
Takahashi, K., Sakamoto, K. & Kimura, J. Hypoxic stress induces transient receptor potential melastatin 2 (TRPM2) channel expression in adult rat cardiac fibroblasts. J. Pharmacol. Sci. 118, 186–197 (2012).
doi: 10.1254/jphs.11128FP
pubmed: 22293297
Kuster, D. W. et al. MicroRNA transcriptome profiling in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutations. J. Mol. Cell. Cardiol. 65, 59–66 (2013).
doi: 10.1016/j.yjmcc.2013.09.012
pubmed: 24083979
Zhainazarov, A. B. Ca
doi: 10.1007/s00232-002-2010-8
pubmed: 12879157
Fonfria, E. et al. Tissue distribution profiles of the human TRPM cation channel family. J. Recept. Signal Transduct. Res. 26, 159–178 (2006).
doi: 10.1080/10799890600637506
pubmed: 16777713
Rose, R. A., Hatano, N., Ohya, S., Imaizumi, Y. & Giles, W. R. C-type natriuretic peptide activates a non-selective cation current in acutely isolated rat cardiac fibroblasts via natriuretic peptide C receptor-mediated signalling. J. Physiol. 580, 255–274 (2007).
pubmed: 17204501
pmcid: 2075416
doi: 10.1113/jphysiol.2006.120832
Zhou, Y., Yi, X., Wang, T. & Li, M. Effects of angiotensin II on transient receptor potential melastatin 7 channel function in cardiac fibroblasts. Exp. Ther. Med. 9, 2008–2012 (2015).
pubmed: 26136930
pmcid: 4471700
doi: 10.3892/etm.2015.2362
Giehl, E. et al. Polycystin 2-dependent cardio-protective mechanisms revealed by cardiac stress. Pflugers Arch. 469, 1507–1517 (2017).
doi: 10.1007/s00424-017-2042-7
Basora, N. et al. Tissue and cellular localization of a novel polycystic kidney disease-like gene product, polycystin-L. J. Am. Soc. Nephrol. 13, 293–301 (2002).
doi: 10.1681/ASN.V132293
pubmed: 11805156
Dvorakova, M. & Kummer, W. Transient expression of vanilloid receptor subtype 1 in rat cardiomyocytes during development. Histochem. Cell Biol. 116, 223–225 (2001).
pubmed: 11685550
doi: 10.1007/s004180100308
Zhong, B. & Wang, D. H. Protease-activated receptor 2-mediated protection of myocardial ischemia-reperfusion injury: role of transient receptor potential vanilloid receptors. Am. J. Physiol. Regul. Integr. Comp. Physiol. 297, R1681–R1690 (2009).
pubmed: 19812353
pmcid: 2803628
doi: 10.1152/ajpregu.90746.2008
Gao, F. et al. TRPV1 activation attenuates high-salt diet-induced cardiac hypertrophy and fibrosis through PPAR-δ upregulation. PPAR Res. 2014, 491963 (2014).
pubmed: 25152753
pmcid: 4131514
doi: 10.1155/2014/491963
Sexton, A., McDonald, M., Cayla, C., Thiemermann, C. & Ahluwalia, A. 12-Lipoxygenase-derived eicosanoids protect against myocardial ischemia/reperfusion injury via activation of neuronal TRPV1. FASEB J. 21, 2695–2703 (2007).
pubmed: 17470568
doi: 10.1096/fj.06-7828com
Buckley, C. L. & Stokes, A. J. Mice lacking functional TRPV1 are protected from pressure overload cardiac hypertrophy. Channels 5, 367–374 (2011).
pubmed: 21814047
pmcid: 3225734
doi: 10.4161/chan.5.4.17083
Horton, J. S., Buckley, C. L. & Stokes, A. J. Successful TRPV1 antagonist treatment for cardiac hypertrophy and heart failure in mice. Channels 7, 17–22 (2013).
pubmed: 23221478
pmcid: 3589277
doi: 10.4161/chan.23006
Lang, H. et al. Activation of TRPV1 attenuates high salt-induced cardiac hypertrophy through improvement of mitochondrial function. Br. J. Pharmacol. 172, 5548–5558 (2015).
pubmed: 25339153
pmcid: 4667858
doi: 10.1111/bph.12987
Wu, Q. F. et al. Activation of transient receptor potential vanilloid 4 involves in hypoxia/reoxygenation injury in cardiomyocytes. Cell Death Dis. 8, e2828 (2017).
pubmed: 28542130
pmcid: 5520739
doi: 10.1038/cddis.2017.227
Ohba, T. et al. Stromal interaction molecule 1 haploinsufficiency causes maladaptive response to pressure overload. PLOS ONE 12, e0187950 (2017).
pubmed: 29145451
pmcid: 5690472
doi: 10.1371/journal.pone.0187950
Satoh, S. et al. Transient receptor potential (TRP) protein 7 acts as a G protein-activated Ca
doi: 10.1007/s11010-006-9261-0
pubmed: 16838106
Iwata, Y. et al. A novel mechanism of myocyte degeneration involving the Ca
pubmed: 12796481
pmcid: 2172975
doi: 10.1083/jcb.200301101