In vitro phosphodiesterase 10A (PDE10A) binding in whole hemisphere human brain using the PET radioligand [
Adult
Aged
Basal Ganglia
/ enzymology
Brain
/ diagnostic imaging
Cadaver
Corpus Striatum
/ enzymology
Female
Fluorine Radioisotopes
Humans
Male
Middle Aged
Neostriatum
/ enzymology
Phosphoric Diester Hydrolases
/ metabolism
Phthalimides
Positron-Emission Tomography
/ methods
Quinazolinones
Radiopharmaceuticals
Autoradiography
Human brain
In vitro binding
PDE10A
[(18)F]MNI-659
Journal
Brain research
ISSN: 1872-6240
Titre abrégé: Brain Res
Pays: Netherlands
ID NLM: 0045503
Informations de publication
Date de publication:
15 05 2019
15 05 2019
Historique:
received:
13
08
2018
revised:
12
01
2019
accepted:
17
01
2019
pubmed:
22
1
2019
medline:
5
8
2020
entrez:
22
1
2019
Statut:
ppublish
Résumé
Highly specific and sensitive biomarkers for pathologies related to dysfunctions in the basal ganglia circuit are of great value to assess therapeutic efficacy not only clinically to establish an early diagnosis, but also in terms of monitoring the efficacy of therapeutic interventions and decelerated neurodegeneration. The phosphodiesterase 10A (PDE10A) enzyme plays a central role in striatal signaling and is implicated in several neuropsychiatric disorders involving striatal pathology, such as Huntingtońs disease (HD) and schizophrenia. Inhibition of PDE10A activates the neurons in the striatum and consequently leads to alteration of behavioral aspects modulated by the striatal circuit. [
Identifiants
pubmed: 30664847
pii: S0006-8993(19)30038-1
doi: 10.1016/j.brainres.2019.01.021
pii:
doi:
Substances chimiques
2-(2-(3-(4-(2-fluoroethoxy)phenyl)-7-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)-4-isopropoxyisoindoline-1,3-dione
0
Fluorine Radioisotopes
0
Phthalimides
0
Quinazolinones
0
Radiopharmaceuticals
0
PDE10A protein, human
EC 3.1.4.-
Phosphoric Diester Hydrolases
EC 3.1.4.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
140-145Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.