Metabolic and proteomic mechanism of benzo[a]pyrene degradation by Brevibacillus brevis.
Benzo[a]pyrene
Biodegradation
Enzyme
Ion
Proteomics
Journal
Ecotoxicology and environmental safety
ISSN: 1090-2414
Titre abrégé: Ecotoxicol Environ Saf
Pays: Netherlands
ID NLM: 7805381
Informations de publication
Date de publication:
15 May 2019
15 May 2019
Historique:
received:
03
12
2018
revised:
07
01
2019
accepted:
10
01
2019
pubmed:
22
1
2019
medline:
12
4
2019
entrez:
22
1
2019
Statut:
ppublish
Résumé
Benzo[a]pyrene (BaP) is a model compound of polycyclic aromatic hydrocarbons. The relationship between its toxicity and some target biomolecules has been investigated. To reveal the interactions of BaP biodegradation and metabolic network, BaP intermediates, proteome, carbon metabolism and ion transport were analyzed. The results show that 76% BaP was degraded by Brevibacillus brevis within 7 d through the cleavage of aromatic rings with the production of 1-naphthol and 2-naphthol. During this process, the expression of xylose isomerase was induced for xylose metabolism, whereas, α-cyclodextrin could no longer be metabolized. Lactic acid, acetic acid and oxalic acid at 0.1-1.2 mg dm
Identifiants
pubmed: 30665150
pii: S0147-6513(19)30053-3
doi: 10.1016/j.ecoenv.2019.01.044
pii:
doi:
Substances chimiques
Naphthols
0
Proteome
0
1-naphthol
2A71EAQ389
Benzo(a)pyrene
3417WMA06D
Carbon
7440-44-0
2-naphthol
P2Z71CIK5H
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-10Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.