Type 1 Diabetes in STAT Protein Family Mutations: Regulating the Th17/Treg Equilibrium and Beyond.
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
12
06
2018
accepted:
11
11
2018
entrez:
23
1
2019
pubmed:
23
1
2019
medline:
6
8
2019
Statut:
ppublish
Résumé
Improvements in the immunological, molecular, and genetic technologies such as next-generation sequencing have led to an exponential increase in the number of monogenic immune dysregulatory syndromes diagnosed, where type 1 diabetes (T1D) forms part of the autoimmune manifestations. Here, we reviewed the mutations in the signal transducer and activator of transcription (STAT) protein family, namely gain-of-function (GOF) mutations in
Identifiants
pubmed: 30665954
pii: 68/2/258
doi: 10.2337/db18-0627
doi:
Substances chimiques
STAT1 Transcription Factor
0
STAT3 Transcription Factor
0
Types de publication
Journal Article
Langues
eng
Pagination
258-265Informations de copyright
© 2019 by the American Diabetes Association.