Generalizing age effects on brain structure and cognition: A two-study comparison approach.
aging
brain structure
cognition
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
01 06 2019
01 06 2019
Historique:
received:
17
07
2018
revised:
27
11
2018
accepted:
08
01
2019
pubmed:
23
1
2019
medline:
14
4
2020
entrez:
23
1
2019
Statut:
ppublish
Résumé
Normal aging is accompanied by an interindividually variable decline in cognitive abilities and brain structure. This variability, in combination with methodical differences and differences in sample characteristics across studies, pose a major challenge for generalizability of results from different studies. Therefore, the current study aimed at cross-validating age-related differences in cognitive abilities and brain structure (measured using cortical thickness [CT]) in two large independent samples, each consisting of 228 healthy older adults aged between 65 and 85 years: the Longitudinal Healthy Aging Brain (LHAB) database (University of Zurich, Switzerland) and the 1000BRAINS (Research Centre Jülich, Germany). Participants from LHAB showed significantly higher education, physical well-being, and cognitive abilities (processing speed, concept shifting, reasoning, semantic verbal fluency, and vocabulary). In contrast, CT values were larger for participants of 1000BRAINS. Though, both samples showed highly similar age-related differences in both, cognitive abilities and CT. These effects were in accordance with functional aging theories, for example, posterior to anterior shift in aging as was shown for the default mode network. Thus, the current two-study approach provides evidence that independently on heterogeneous metrics of brain structure or cognition across studies, age-related effects on cognitive ability and brain structure can be generalized over different samples, assuming the same methodology is used.
Identifiants
pubmed: 30666760
doi: 10.1002/hbm.24524
pmc: PMC6590363
doi:
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2305-2319Subventions
Organisme : European Union's Horizon 2020 Research and Innovation Programme (SGA1, SGA2)
ID : 720270
Pays : International
Organisme : European Union's Horizon 2020 Research and Innovation Programme (SGA1, SGA2)
ID : 785907
Pays : International
Organisme : Swiss National Foundation for Scientific Exchange
ID : 174247
Pays : International
Organisme : Velux Stiftung
ID : 369
Pays : International
Informations de copyright
© 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.
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