Acute and Delayed Deaths after West Nile Virus Infection, Texas, USA, 2002-2012.
Texas
United States
WNND
WNV
West Nile neuroinvasive disease
West Nile virus
acute deaths
delayed deaths
hazard ratios
meningitis/encephalitis
standardized mortality ratios
survival analysis
viruses
Journal
Emerging infectious diseases
ISSN: 1080-6059
Titre abrégé: Emerg Infect Dis
Pays: United States
ID NLM: 9508155
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
entrez:
23
1
2019
pubmed:
23
1
2019
medline:
30
7
2019
Statut:
ppublish
Résumé
Infection with West Nile virus (WNV) has a well-characterized acute disease process. However, long-term consequences are less understood. We searched death records for 4,142 residents of Texas, USA, infected with WNV during 2002-2012 and identified 557 (13%) deaths. We analyzed all-cause and cause-specific deaths after WNV infection by calculating standardized mortality ratios and using statewide mortality data. Acute-phase deaths (<90 days after symptom onset) occurred in 289 (7%) of case-patients; of those deaths, 289 (92%) were cases of West Nile neuroinvasive disease (WNND). Convalescent-phase deaths (>90 days after symptom onset) occurred in 268 (7%) of the remaining 3,853 case-patients; 210 (78%) of these deaths occurred in patients with WNND. Convalescent-phase WNND case-patients showed excess deaths from infectious and renal causes; case-patients <60 years of age had increased risk for all-cause death, specifically from renal, infectious, digestive, and circulatory causes. We provide population-level evidence of increased risk for death after WNV infection resulting in WNND.
Identifiants
pubmed: 30667356
doi: 10.3201/eid2502.181250
pmc: PMC6346437
doi:
Types de publication
Historical Article
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI091816
Pays : United States
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