The prevalence of osteoarthritis: Higher risk after transfemoral amputation?-A database analysis with 1,569 amputees and matched controls.
Adolescent
Adult
Aged
Aged, 80 and over
Amputation, Surgical
/ adverse effects
Amputees
Arthritis
/ epidemiology
Back Pain
/ epidemiology
Case-Control Studies
Child
Female
Femur
/ surgery
Germany
/ epidemiology
Humans
Leg
Male
Middle Aged
Osteoarthritis
/ epidemiology
Osteoarthritis, Hip
/ epidemiology
Osteoarthritis, Knee
/ epidemiology
Prevalence
Risk Factors
Spinal Diseases
/ epidemiology
Spinal Osteochondrosis
/ epidemiology
Young Adult
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
19
06
2018
accepted:
03
01
2019
entrez:
23
1
2019
pubmed:
23
1
2019
medline:
2
11
2019
Statut:
epublish
Résumé
Several studies have shown that patients with a unilateral amputation have an increased risk of developing osteoarthritis (OA) in the knee of their sound leg. OBJECTIVE: The first objective was to investigate whether amputees are more frequently affected by gon-, cox- or polyarthritis as well as back pain or spinal disorders. We hypothesized that mobile and active transfemoral amputees more often experience OA and spinal disorders than non-amputees. The second objective was to compare the mean age of the patients with OA. Patients with a unilateral transfemoral amputation (n = 1,569) and five abled-body control groups (each n = 1,569) matched in terms of age and gender resulting in total of 9,414 participants. Groups were analyzed regarding the prevalence of six selected diagnoses regarding musculoskeletal disorders. A significantly decreased prevalence of OA and specific disorders of the spine in transfemoral amputees compared to a control group was found. The amputees with OA are significantly younger than patients with OA in the control group. The results from the presented study contradict previously published literature. Apparently circumstances of life play an important role, like physical work and strenuous activities which are likely to be underrepresented in the amputee group. The results of the study need to be used cautiously due to the major limitation of the study which is the lack of detail in individual patients caused by the methodology.
Sections du résumé
BACKGROUND
Several studies have shown that patients with a unilateral amputation have an increased risk of developing osteoarthritis (OA) in the knee of their sound leg. OBJECTIVE: The first objective was to investigate whether amputees are more frequently affected by gon-, cox- or polyarthritis as well as back pain or spinal disorders. We hypothesized that mobile and active transfemoral amputees more often experience OA and spinal disorders than non-amputees. The second objective was to compare the mean age of the patients with OA.
PATIENTS
Patients with a unilateral transfemoral amputation (n = 1,569) and five abled-body control groups (each n = 1,569) matched in terms of age and gender resulting in total of 9,414 participants.
METHODS
Groups were analyzed regarding the prevalence of six selected diagnoses regarding musculoskeletal disorders.
RESULTS
A significantly decreased prevalence of OA and specific disorders of the spine in transfemoral amputees compared to a control group was found. The amputees with OA are significantly younger than patients with OA in the control group.
CONCLUSION
The results from the presented study contradict previously published literature. Apparently circumstances of life play an important role, like physical work and strenuous activities which are likely to be underrepresented in the amputee group. The results of the study need to be used cautiously due to the major limitation of the study which is the lack of detail in individual patients caused by the methodology.
Identifiants
pubmed: 30668582
doi: 10.1371/journal.pone.0210868
pii: PONE-D-18-17718
pmc: PMC6342302
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0210868Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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