Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+, Th2/IL-22+, Th0/IL-22+), Which Also Produce IL-4, Are Involved in the Success of Pregnancy.
Abortion, Habitual
/ etiology
Biomarkers
CD4-Positive T-Lymphocytes
/ immunology
Cytokines
/ biosynthesis
Decidua
/ physiology
Female
Humans
Interleukin-4
/ biosynthesis
Interleukins
/ biosynthesis
Models, Biological
Pregnancy
Pregnancy Outcome
Pregnancy, Ectopic
/ etiology
T-Lymphocyte Subsets
/ immunology
Interleukin-22
IL-17
IL-22
IL-4
IL-5
Th17
Th22
ectopic pregnancy
implantation
pregnancy
spontaneous abortion
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Jan 2019
19 Jan 2019
Historique:
received:
18
12
2018
revised:
16
01
2019
accepted:
17
01
2019
entrez:
24
1
2019
pubmed:
24
1
2019
medline:
2
5
2019
Statut:
epublish
Résumé
Trophoblast expressing paternal HLA-C resembles a semiallograft, and could be rejected by maternal T cells. IL-22 seems to be involved in allograft rejection and thus could be responsible for miscarriages. We examined the role of decidual IL-22-producing CD4+ T on human pregnancy. In those experiencing successful pregnancy and those experiencing unexplained recurrent abortion (URA), the levels of IL-22 produced by decidual CD4+ T cells are higher than those of peripheral blood T cells. We found a correlation of IL-22 and IL-4 produced by decidual CD4+ T cells in those experiencing successful pregnancy, not in those experiencing URA. The correlation of IL-22 and IL-4 was also found in the serum of successful pregnancy. A prevalence of CD4+ T cells producing IL-22 and IL-4 (Th17/Th2/IL-22+, Th17/Th0/IL-22+, Th17/Th2/IL-22+, and Th0/IL-22+ cells) was observed in decidua of those experiencing successful pregnancy, whereas Th17/Th1/IL-22+ cells, which do not produce IL-4, are prevalent in those experiencing URA. Th17/Th2/IL-22+ and Th17/Th0/IL-22+ cells are exclusively present at the embryo implantation site where IL-4, GATA-3, IL-17A, ROR-C, IL-22, and AHR mRNA are expressed. T-bet and IFN-γ mRNA are found away from the implantation site. There is no pathogenic role of IL-22 when IL-4 is also produced by decidual CD4+ cells. Th17/Th2/IL-22+ and Th17/Th0/IL-22+ cells seem to be crucial for embryo implantation.
Identifiants
pubmed: 30669479
pii: ijms20020428
doi: 10.3390/ijms20020428
pmc: PMC6359245
pii:
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
Interleukins
0
Interleukin-4
207137-56-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European NoE EMBIC
ID : LSHM-CT-2004-512040
Organisme : Intramural Scientific Research (ex-60%) of the University of Florence
ID : RICATEN18
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