The Many Faces of FKBP51.
FK506
FKBP51
GR
Hsp90
NF-κB
SAFit
glucocorticoids
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
21 01 2019
21 01 2019
Historique:
received:
07
12
2018
revised:
14
01
2019
accepted:
14
01
2019
entrez:
24
1
2019
pubmed:
24
1
2019
medline:
14
6
2019
Statut:
epublish
Résumé
The FK506-binding protein 51 (FKBP51) has emerged as a key regulator of endocrine stress responses in mammals and as a potential therapeutic target for stress-related disorders (depression, post-traumatic stress disorder), metabolic disorders (obesity and diabetes) and chronic pain. Recently, FKBP51 has been implicated in several cellular pathways and numerous interacting protein partners have been reported. However, no consensus on the underlying molecular mechanisms has yet emerged. Here, we review the protein interaction partners reported for FKBP51, the proposed pathways involved, their relevance to FKBP51's physiological function(s), the interplay with other FKBPs, and implications for the development of FKBP51-directed drugs.
Identifiants
pubmed: 30669684
pii: biom9010035
doi: 10.3390/biom9010035
pmc: PMC6359276
pii:
doi:
Substances chimiques
Glucocorticoids
0
HSP90 Heat-Shock Proteins
0
NF-kappa B
0
Receptors, Steroid
0
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Tacrolimus Binding Proteins
EC 5.2.1.-
tacrolimus binding protein 5
EC 5.2.1.8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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