Neurite-Enriched MicroRNA-218 Stimulates Translation of the GluA2 Subunit and Increases Excitatory Synaptic Strength.
GluA2
Homeostatic plasticity
Local translation
Neurite-specific microRNAs
Journal
Molecular neurobiology
ISSN: 1559-1182
Titre abrégé: Mol Neurobiol
Pays: United States
ID NLM: 8900963
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
04
07
2018
accepted:
10
01
2019
pubmed:
24
1
2019
medline:
18
12
2019
entrez:
24
1
2019
Statut:
ppublish
Résumé
Local control of protein translation is a fundamental process for the regulation of synaptic plasticity. It has been demonstrated that the local protein synthesis occurring in axons and dendrites can be shaped by numerous mechanisms, including miRNA-mediated regulation. However, several aspects underlying this regulatory process have not been elucidated yet. Here, we analyze the differential miRNA profile in cell bodies and neurites of primary hippocampal neurons and find an enrichment of the precursor and mature forms of miR-218 in the neuritic projections. We show that miR-218 abundance is regulated during hippocampal development and by chronic silencing or activation of neuronal network. Overexpression and knockdown of miR-218 demonstrated that miR-218 targets the mRNA encoding the GluA2 subunit of AMPA receptors and modulates its expression. At the functional level, miR-218 overexpression increases glutamatergic synaptic transmission at both single neuron and network levels. Our data demonstrate that miR-218 may play a key role in the regulation of AMPA-mediated excitatory transmission and in the homeostatic regulation of synaptic plasticity.
Identifiants
pubmed: 30671783
doi: 10.1007/s12035-019-1492-7
pii: 10.1007/s12035-019-1492-7
doi:
Substances chimiques
MIRN218 microRNA, mouse
0
MicroRNAs
0
Protein Subunits
0
Receptors, AMPA
0
glutamate receptor ionotropic, AMPA 2
P6W5IXV8V9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5701-5714Subventions
Organisme : Italian Ministry of Health Ricerca Finalizzata
ID : GR-2013-02355540
Organisme : Compagnia di San Paolo
ID : 2015.0546
Organisme : Compagnia di San Paolo
ID : 2017.0589
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