Gabriele Lignani

Affiliations

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, Queen Square House, London, WC1N 3BG, UK. g.lignani@ucl.ac.uk.

ORCID: http://orcid.org/0000-0002-3963-9296

Publications (23)

Gene Editing and Modulation: the Holy Grail for the Genetic Epilepsies?

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Avec: Jenna C Carpenter , Gabriele Lignani

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Cellular and molecular life sciences : CMLS

Avec: Matteo Moschetta , Tiziana Ravasenga , Antonio De Fusco , Luca Maragliano , Davide Aprile , Marta Orlando , Silvio Sacchetti , Silvia Casagrande , Gabriele Lignani , Anna Fassio , Pietro Baldelli , Fabio Benfenati

Epg5 links proteotoxic stress due to defective autophagic clearance and epileptogenesis in

Autophagy

Avec: Celine Deneubourg , Hormos Salimi Dafsari , Simon Lowe , Aitana Martinez-Cotrina , David Mazaud , Seo Hyun Park , Virginia Vergani , Amanda Almacellas Barbanoj , Reza Maroofian , Luisa Averdunk , Ehsan Ghayoor-Karimiani , Sandeep Jayawant , Cyril Mignot , Boris Keren , Renate Peters , Arveen Kamath , Lauren Mattas , Sumit Verma , Arpana Silwal , Felix Distelmaier , Henry Houlden , Gabriele Lignani , Adam Antebi , James Jepson , Heinz Jungbluth , Manolis Fanto

Synapsin I Controls Synaptic Maturation of Long-Range Projections in the Lateral Amygdala in a Targeted Selective Fashion.

Frontiers in cellular neuroscience

Avec: Eleonora Lugarà , Antonio De Fusco , Gabriele Lignani , Fabio Benfenati , Yann Humeau

Progressive myoclonus epilepsy KCNC1 variant causes a developmental dendritopathy.

Epilepsia

Avec: Jenna C Carpenter , Roope Männikkö , Catherine Heffner , Jana Heneine , Marisol Sampedro-Castañeda , Gabriele Lignani , Stephanie Schorge

Electrophysiological Properties of Human Cortical Organoids: Current State of the Art and Future Directions.

Frontiers in molecular neuroscience

Avec: Clara Zourray , Manju A Kurian , Serena Barral , Gabriele Lignani

Early developmental alterations of CA1 pyramidal cells in Dravet syndrome.

Neurobiology of disease

Avec: Steffan P Jones , Nathanael O'Neill , Jenna C Carpenter , Sharon Muggeo , Gaia Colasante , Dimitri M Kullmann , Gabriele Lignani

Recent advances in gene therapy for neurodevelopmental disorders with epilepsy.

Journal of neurochemistry

Avec: Thomas J Turner , Clara Zourray , Stephanie Schorge , Gabriele Lignani

dCas9-Based Scn1a Gene Activation Restores Inhibitory Interneuron Excitability and Attenuates Seizures in Dravet Syndrome Mice.

Molecular therapy : the journal of the American Society of Gene Therapy

Avec: Gaia Colasante , Gabriele Lignani , Simone Brusco , Claudia Di Berardino , Jenna Carpenter , Serena Giannelli , Nicholas Valassina , Simone Bido , Raffaele Ricci , Valerio Castoldi , Silvia Marenna , Timothy Church , Luca Massimino , Giuseppe Morabito , Fabio Benfenati , Stephanie Schorge , Letizia Leocani , Dimitri M Kullmann , Vania Broccoli

LGI1 downregulation increases neuronal circuit excitability.

Epilepsia

Avec: Eleonora Lugarà , Rahul Kaushik , Marco Leite , Elodie Chabrol , Alexander Dityatev , Gabriele Lignani , Matthew C Walker

REST/NRSF drives homeostatic plasticity of inhibitory synapses in a target-dependent fashion.

eLife

Avec: Cosimo Prestigio , Daniele Ferrante , Antonella Marte , Alessandra Romei , Gabriele Lignani , Franco Onofri , Pierluigi Valente , Fabio Benfenati , Pietro Baldelli

On-demand cell-autonomous gene therapy for brain circuit disorders.

Science (New York, N.Y.)

Avec: Yichen Qiu , Nathanael O'Neill , Benito Maffei , Clara Zourray , Amanda Almacellas-Barbanoj , Jenna C Carpenter , Steffan P Jones , Marco Leite , Thomas J Turner , Francisco C Moreira , Albert Snowball , Tawfeeq Shekh-Ahmad , Vincent Magloire , Serena Barral , Manju A Kurian , Matthew C Walker , Stephanie Schorge , Dimitri M Kullmann , Gabriele Lignani

Anti-seizure gene therapy for focal cortical dysplasia.

Brain : a journal of neurology

Avec: Amanda Almacellas Barbanoj , Robert T Graham , Benito Maffei , Jenna C Carpenter , Marco Leite , Justin Hoke , Felisia Hardjo , James Scott-Solache , Christos Chimonides , Stephanie Schorge , Dimitri M Kullmann , Vincent Magloire , Gabriele Lignani

Homeostatic Plasticity in Epilepsy.

Frontiers in cellular neuroscience

Avec: Gabriele Lignani , Pietro Baldelli , Vincenzo Marra

Neurite-Enriched MicroRNA-218 Stimulates Translation of the GluA2 Subunit and Increases Excitatory Synaptic Strength.

Molecular neurobiology

Avec: Anna Rocchi , Daniela Moretti , Gabriele Lignani , Elisabetta Colombo , Joachim Scholz-Starke , Pietro Baldelli , Tatiana Tkatch , Fabio Benfenati

Aromatic l-amino acid decarboxylase deficiency: a patient-derived neuronal model for precision therapies.

Brain : a journal of neurology

Avec: Giada Rossignoli , Karolin Krämer , Eleonora Lugarà , Haya Alrashidi , Simon Pope , Carmen De La Fuente Barrigon , Katy Barwick , Giovanni Bisello , Joanne Ng , John Counsell , Gabriele Lignani , Simon J R Heales , Mariarita Bertoldi , Serena Barral , Manju A Kurian

Neurodevelopmental and synaptic defects in DNAJC6 parkinsonism, amenable to gene therapy.

Brain : a journal of neurology

Avec: Lucia Abela , Lorita Gianfrancesco , Erica Tagliatti , Giada Rossignoli , Katy Barwick , Clara Zourray , Kimberley M Reid , Dimitri Budinger , Joanne Ng , John Counsell , Arlo Simpson , Toni S Pearson , Simon Edvardson , Orly Elpeleg , Frances M Brodsky , Gabriele Lignani , Serena Barral , Manju A Kurian

Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability.

Nature communications

Avec: Marisol Sampedro-Castañeda , Lucas L Baltussen , André T Lopes , Yichen Qiu , Liina Sirvio , Simeon R Mihaylov , Suzanne Claxton , Jill C Richardson , Gabriele Lignani , Sila K Ultanir

Reusable, flexible, and lightweight chronic implants for Neuropixels probes.

bioRxiv : the preprint server for biology

Avec: C Bimbard , F Takacs , J M J Fabre , M D Melin , N O'Neill , M Robacha , J S Street , E H VAN Beest , A K Churchland , K D Harris , D M Kullmann , G Lignani , M Carandini , P Coen

In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy.

Brain : a journal of neurology

Avec: Gaia Colasante , Yichen Qiu , Luca Massimino , Claudia Di Berardino , Jonathan H Cornford , Albert Snowball , Mikail Weston , Steffan P Jones , Serena Giannelli , Andreas Lieb , Stephanie Schorge , Dimitri M Kullmann , Vania Broccoli , Gabriele Lignani

Olanzapine: A potent agonist at the hM4D(Gi) DREADD amenable to clinical translation of chemogenetics.

Science advances

Avec: Mikail Weston , Teresa Kaserer , Angela Wu , Alexandre Mouravlev , Jenna C Carpenter , Albert Snowball , Samuel Knauss , Melanie von Schimmelmann , Matthew J During , Gabriele Lignani , Stephanie Schorge , Deborah Young , Dimitri M Kullmann , Andreas Lieb

Scn1a gene reactivation after symptom onset rescues pathological phenotypes in a mouse model of Dravet syndrome.

Nature communications

Avec: Nicholas Valassina , Simone Brusco , Alessia Salamone , Linda Serra , Mirko Luoni , Serena Giannelli , Simone Bido , Luca Massimino , Federica Ungaro , Pietro Giuseppe Mazzara , Patrizia D'Adamo , Gabriele Lignani , Vania Broccoli , Gaia Colasante

Gene therapy restores dopamine transporter expression and ameliorates pathology in iPSC and mouse models of infantile parkinsonism.

Science translational medicine

Avec: Joanne Ng , Serena Barral , Carmen De La Fuente Barrigon , Gabriele Lignani , Fatma A Erdem , Rebecca Wallings , Riccardo Privolizzi , Giada Rossignoli , Haya Alrashidi , Sonja Heasman , Esther Meyer , Adeline Ngoh , Simon Pope , Rajvinder Karda , Dany Perocheau , Julien Baruteau , Natalie Suff , Juan Antinao Diaz , Stephanie Schorge , Jane Vowles , Lucy R Marshall , Sally A Cowley , Sonja Sucic , Michael Freissmuth , John R Counsell , Richard Wade-Martins , Simon J R Heales , Ahad A Rahim , Maximilien Bencze , Simon N Waddington , Manju A Kurian

Réseau de co-auteurs

Stephanie Schorge 8 collaborations

Jenna C Carpenter 6 collaborations

Dimitri M Kullmann 6 collaborations

Fabio Benfenati 5 collaborations

Manju A Kurian 5 collaborations

Serena Barral 5 collaborations

Pietro Baldelli 4 collaborations

Clara Zourray 4 collaborations

Gaia Colasante 4 collaborations

Eleonora Lugarà 3 collaborations

Steffan P Jones 3 collaborations

Serena Giannelli 3 collaborations

Luca Massimino 3 collaborations

Vania Broccoli 3 collaborations

Marco Leite 3 collaborations

Yichen Qiu 3 collaborations

Albert Snowball 3 collaborations

Giada Rossignoli 3 collaborations

Joanne Ng 3 collaborations

Antonio De Fusco 2 collaborations

Amanda Almacellas Barbanoj 2 collaborations

Marisol Sampedro-Castañeda 2 collaborations

Nathanael O'Neill 2 collaborations

Thomas J Turner 2 collaborations

Simone Brusco 2 collaborations

Claudia Di Berardino 2 collaborations

Nicholas Valassina 2 collaborations

Simone Bido 2 collaborations

Matthew C Walker 2 collaborations

Benito Maffei 2 collaborations

Vincent Magloire 2 collaborations

Haya Alrashidi 2 collaborations

Simon Pope 2 collaborations

Carmen De La Fuente Barrigon 2 collaborations

Katy Barwick 2 collaborations

John Counsell 2 collaborations

Simon J R Heales 2 collaborations

Mikail Weston 2 collaborations

Andreas Lieb 2 collaborations

Matteo Moschetta 1 collaboration

Tiziana Ravasenga 1 collaboration

Luca Maragliano 1 collaboration

Davide Aprile 1 collaboration

Marta Orlando 1 collaboration

Silvio Sacchetti 1 collaboration

Silvia Casagrande 1 collaboration

Anna Fassio 1 collaboration

Celine Deneubourg 1 collaboration

Hormos Salimi Dafsari 1 collaboration

Simon Lowe 1 collaboration

Aitana Martinez-Cotrina 1 collaboration

David Mazaud 1 collaboration

Seo Hyun Park 1 collaboration

Virginia Vergani 1 collaboration

Reza Maroofian 1 collaboration

Luisa Averdunk 1 collaboration

Ehsan Ghayoor-Karimiani 1 collaboration

Sandeep Jayawant 1 collaboration

Cyril Mignot 1 collaboration

Boris Keren 1 collaboration

Renate Peters 1 collaboration

Arveen Kamath 1 collaboration

Lauren Mattas 1 collaboration

Sumit Verma 1 collaboration

Arpana Silwal 1 collaboration

Felix Distelmaier 1 collaboration

Henry Houlden 1 collaboration

Adam Antebi 1 collaboration

James Jepson 1 collaboration

Heinz Jungbluth 1 collaboration

Manolis Fanto 1 collaboration

Yann Humeau 1 collaboration

Roope Männikkö 1 collaboration

Catherine Heffner 1 collaboration

Jana Heneine 1 collaboration

Sharon Muggeo 1 collaboration

Jenna Carpenter 1 collaboration

Raffaele Ricci 1 collaboration

Valerio Castoldi 1 collaboration

Silvia Marenna 1 collaboration

Timothy Church 1 collaboration

Giuseppe Morabito 1 collaboration

Letizia Leocani 1 collaboration

Rahul Kaushik 1 collaboration

Elodie Chabrol 1 collaboration

Alexander Dityatev 1 collaboration

Cosimo Prestigio 1 collaboration

Daniele Ferrante 1 collaboration

Antonella Marte 1 collaboration

Alessandra Romei 1 collaboration

Franco Onofri 1 collaboration

Pierluigi Valente 1 collaboration

Amanda Almacellas-Barbanoj 1 collaboration

Francisco C Moreira 1 collaboration

Tawfeeq Shekh-Ahmad 1 collaboration

Robert T Graham 1 collaboration

Justin Hoke 1 collaboration

Felisia Hardjo 1 collaboration

James Scott-Solache 1 collaboration

Christos Chimonides 1 collaboration

Vincenzo Marra 1 collaboration

Anna Rocchi 1 collaboration

Daniela Moretti 1 collaboration

Elisabetta Colombo 1 collaboration

Joachim Scholz-Starke 1 collaboration

Tatiana Tkatch 1 collaboration

Karolin Krämer 1 collaboration

Giovanni Bisello 1 collaboration

Mariarita Bertoldi 1 collaboration

Lucia Abela 1 collaboration

Lorita Gianfrancesco 1 collaboration

Erica Tagliatti 1 collaboration

Kimberley M Reid 1 collaboration

Dimitri Budinger 1 collaboration

Arlo Simpson 1 collaboration

Toni S Pearson 1 collaboration

Simon Edvardson 1 collaboration

Orly Elpeleg 1 collaboration

Frances M Brodsky 1 collaboration

Lucas L Baltussen 1 collaboration

André T Lopes 1 collaboration

Liina Sirvio 1 collaboration

Simeon R Mihaylov 1 collaboration

Suzanne Claxton 1 collaboration

Jill C Richardson 1 collaboration

Sila K Ultanir 1 collaboration

C Bimbard 1 collaboration

F Takacs 1 collaboration

J M J Fabre 1 collaboration

M D Melin 1 collaboration

N O'Neill 1 collaboration

M Robacha 1 collaboration

J S Street 1 collaboration

E H VAN Beest 1 collaboration

A K Churchland 1 collaboration

K D Harris 1 collaboration

D M Kullmann 1 collaboration

G Lignani 1 collaboration

M Carandini 1 collaboration

P Coen 1 collaboration

Jonathan H Cornford 1 collaboration

Teresa Kaserer 1 collaboration

Angela Wu 1 collaboration

Alexandre Mouravlev 1 collaboration

Samuel Knauss 1 collaboration

Melanie von Schimmelmann 1 collaboration

Matthew J During 1 collaboration

Deborah Young 1 collaboration

Alessia Salamone 1 collaboration

Linda Serra 1 collaboration

Mirko Luoni 1 collaboration

Federica Ungaro 1 collaboration

Pietro Giuseppe Mazzara 1 collaboration

Patrizia D'Adamo 1 collaboration

Fatma A Erdem 1 collaboration

Rebecca Wallings 1 collaboration

Riccardo Privolizzi 1 collaboration

Sonja Heasman 1 collaboration

Esther Meyer 1 collaboration

Adeline Ngoh 1 collaboration

Rajvinder Karda 1 collaboration

Dany Perocheau 1 collaboration

Julien Baruteau 1 collaboration

Natalie Suff 1 collaboration

Juan Antinao Diaz 1 collaboration

Jane Vowles 1 collaboration

Lucy R Marshall 1 collaboration

Sally A Cowley 1 collaboration

Sonja Sucic 1 collaboration

Michael Freissmuth 1 collaboration

John R Counsell 1 collaboration

Richard Wade-Martins 1 collaboration

Ahad A Rahim 1 collaboration

Maximilien Bencze 1 collaboration

Simon N Waddington 1 collaboration