Hepatic effects of long-term tamoxifen administration to cycling female rats.
biochemical parameters
cycling female rats
histomorphology
liver
tamoxifen
Journal
Journal of biochemical and molecular toxicology
ISSN: 1099-0461
Titre abrégé: J Biochem Mol Toxicol
Pays: United States
ID NLM: 9717231
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
30
07
2018
revised:
02
01
2019
accepted:
04
01
2019
pubmed:
24
1
2019
medline:
18
6
2019
entrez:
24
1
2019
Statut:
ppublish
Résumé
The metabolic implications of tamoxifen (TAM) used as preventive therapy of young premenopausal women with high risk of breast cancer is unknown. To unravel this problem, an animal model of long-term TAM administration to cycling young adult female rats was used to evaluate its effects in the liver. Body weight and food consumption were monitored, and at the end of the study, both parameters were lower in TAM-treated rats. Biochemical measurements showed that the TAM administration induced alterations in serum levels of liver enzymes when compared with control rats at different stages of the estrous cycle. In TAM-treated rats, lower glycogen storage was observed in hepatocytes close to the portal areas and pericentrolobular cells had a higher concentration of glycogen. Liver sections of TAM-treated rats presented mild steatosis-a high percentage of area occupied by lipid droplets in the hepatocytes. These results point to metabolic changes upon long-term TAM therapy.
Substances chimiques
Tamoxifen
094ZI81Y45
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e22293Subventions
Organisme : Fundação para a Ciência e Tecnologia
ID : UID/IC/4255/2013
Organisme : Cooperativa de Ensino Superior Politécnico e Universitário
ID : TAMeteffects-CESPU-2016
Informations de copyright
© 2019 Wiley Periodicals, Inc.