Adipocyte Mineralocorticoid Receptor.

Adipocytes / metabolism Aldosterone / metabolism Animals Cytochrome P-450 CYP11B2 / antagonists & inhibitors Gene Expression Regulation / physiology Mineralocorticoid Receptor Antagonists Receptors, Mineralocorticoid / genetics
Adipose tissue Adrenal glands Aldosterone Browning Metabolic syndrome Obesity

Journal

Vitamins and hormones
ISSN: 0083-6729
Titre abrégé: Vitam Horm
Pays: United States
ID NLM: 0413601

Informations de publication

Date de publication:
2019
Historique:
entrez: 26 1 2019
pubmed: 27 1 2019
medline: 23 4 2019
Statut: ppublish

Résumé

Mineralocorticoid receptor (MR) has been recently identified in adipose tissue, where its excessive activation contributes to several metabolic derangements often observed in obesity and metabolic syndrome. Recent findings support the existence of a bidirectional cross-talk between adipose tissue and adrenal glands, contributing to obesity-related hyperaldosteronism and subsequent adipocyte MR excessive activation. In this regard, MR pharmacological blockade has led to prevention of weight gain and metabolic benefits in murine models of genetic or diet-induced obesity. However, there is still a lack of knowledge on the potential metabolic effects of MR antagonists in clinical settings. Hence, larger clinical studies are deemed necessary to clarify the role of MR antagonism in obesity and metabolic syndrome in humans.

Identifiants

DOI: 10.1016/bs.vh.2018.10.005 PMID: 30678856
pubmed: 30678856
pii: S0083-6729(18)30077-3
doi: 10.1016/bs.vh.2018.10.005
pii:
doi:

Substances chimiques

Mineralocorticoid Receptor Antagonists 0
Receptors, Mineralocorticoid 0
Aldosterone 4964P6T9RB
Cytochrome P-450 CYP11B2 EC 1.14.15.4

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

189-209

Informations de copyright

© 2019 Elsevier Inc. All rights reserved.

Auteurs

Marco Infante (M)

Unit of Endocrinology and Metabolic Diseases, Department of Systems Medicine, CTO A. Alesini Hospital, ASL Roma 2, University Tor Vergata, Rome, Italy.

Andrea Armani (A)

Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Pisana, Rome, Italy.

Vincenzo Marzolla (V)

Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Pisana, Rome, Italy.

Andrea Fabbri (A)

Unit of Endocrinology and Metabolic Diseases, Department of Systems Medicine, CTO A. Alesini Hospital, ASL Roma 2, University Tor Vergata, Rome, Italy.

Massimiliano Caprio (M)

Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Pisana, Rome, Italy; Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, Rome, Italy. Electronic address: massimiliano.caprio@sanraffaele.it.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Adipocytes › Adipocyte Mineralocorticoid Receptor.
questionsmedicales.fr › Hormones corticosurrénaliennes › Hydroxycorticostéroïdes › 11-Hydroxycorticostéroïdes › Aldostérone › Adipocyte Mineralocorticoid Receptor.
questionsmedicales.fr › Eucaryotes › Animaux › Adipocyte Mineralocorticoid Receptor.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Steroid hydroxylases › Cytochrome P-450 CYP11B2 › Adipocyte Mineralocorticoid Receptor.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Adipocyte Mineralocorticoid Receptor.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Diurétiques › Diurétiques d'épargne potassique › Antagonistes des récepteurs des minéralocorticoïdes › Adipocyte Mineralocorticoid Receptor.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteurs des minéralocorticoïdes › Adipocyte Mineralocorticoid Receptor.