Allylbenzene Derivatives
Animals
Anisoles
/ pharmacology
Calcium Channels
/ metabolism
Foeniculum
/ chemistry
HEK293 Cells
Humans
Isothiocyanates
/ pharmacology
Mice
Mice, Inbred C57BL
Oils, Volatile
/ pharmacology
Sensory Receptor Cells
/ drug effects
Spinal Nerve Roots
/ drug effects
TRPA1 Cation Channel
/ agonists
Transient Receptor Potential Channels
/ metabolism
Trigeminal Ganglion
/ drug effects
Journal
Molecular pharmacology
ISSN: 1521-0111
Titre abrégé: Mol Pharmacol
Pays: United States
ID NLM: 0035623
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
16
09
2018
accepted:
18
01
2019
pubmed:
27
1
2019
medline:
15
6
2019
entrez:
26
1
2019
Statut:
ppublish
Résumé
Transient receptor potential (TRP) cation channels are molecular targets of various natural products. TRPA1, a member of TRP channel family, is specifically activated by natural products such as allyl isothiocyanate (mustard oil), cinnamaldehyde (cinnamon), and allicin (garlic). In this study, we demonstrated that TRPA1 is also a target of
Identifiants
pubmed: 30679204
pii: mol.118.114561
doi: 10.1124/mol.118.114561
pmc: PMC6408737
doi:
Substances chimiques
Allylbenzene Derivatives
0
Anisoles
0
Calcium Channels
0
Isothiocyanates
0
Oils, Volatile
0
TRPA1 Cation Channel
0
TRPA1 protein, human
0
Transient Receptor Potential Channels
0
fennel oil, bitter
8006-84-6
allyl isothiocyanate
BN34FX42G3
anethole
Q3JEK5DO4K
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
433-441Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES017431
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY022076
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY014800
Pays : United States
Organisme : NIGMS NIH HHS
ID : P01 GM048677
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY027920
Pays : United States
Informations de copyright
Copyright © 2019 by The American Society for Pharmacology and Experimental Therapeutics.
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