A child with perinatal HIV infection and long-term sustained virological control following antiretroviral treatment cessation.
Anti-HIV Agents
/ therapeutic use
CD4-Positive T-Lymphocytes
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
Child
Cytokines
/ analysis
DNA, Viral
Female
Genotype
HIV Antibodies
/ blood
HIV Infections
/ drug therapy
HIV-1
/ genetics
Humans
Immunity, Cellular
Immunophenotyping
Infant, Newborn
Phosphoproteins
/ genetics
Pregnancy
RNA, Viral
Receptors, CCR5
/ metabolism
Receptors, KIR
/ genetics
Receptors, KIR3DL1
/ genetics
Viral Load
Withholding Treatment
gag Gene Products, Human Immunodeficiency Virus
/ genetics
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
24 01 2019
24 01 2019
Historique:
received:
16
05
2018
accepted:
03
01
2019
entrez:
26
1
2019
pubmed:
27
1
2019
medline:
23
2
2019
Statut:
epublish
Résumé
Understanding HIV remission in rare individuals who initiated antiretroviral therapy (ART) soon after infection and then discontinued, may inform HIV cure interventions. Here we describe features of virus and host of a perinatally HIV-1 infected child with long-term sustained virological control. The child received early limited ART in the Children with HIV Early antiRetroviral therapy (CHER) trial. At age 9.5 years, diagnostic tests for HIV are negative and the child has characteristics similar to uninfected children that include a high CD4:CD8 ratio, low T cell activation and low CCR5 expression. Virus persistence (HIV-1 DNA and plasma RNA) is confirmed with sensitive methods, but replication-competent virus is not detected. The child has weak HIV-specific antibody and T cell responses. Furthermore, we determine his HLA and KIR genotypes. This case aids in understanding post-treatment control and may help design of future intervention strategies.
Identifiants
pubmed: 30679439
doi: 10.1038/s41467-019-08311-0
pii: 10.1038/s41467-019-08311-0
pmc: PMC6345921
doi:
Substances chimiques
Anti-HIV Agents
0
CCR5 protein, human
0
Cytokines
0
DNA, Viral
0
HIV Antibodies
0
KIR2DS4 protein, human
0
KIR3DL1 protein, human
0
La protein, human
0
Phosphoproteins
0
RNA, Viral
0
Receptors, CCR5
0
Receptors, KIR
0
Receptors, KIR3DL1
0
gag Gene Products, Human Immunodeficiency Virus
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
412Subventions
Organisme : NICHD NIH HHS
ID : R01 HD073952
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH019105
Pays : United States
Organisme : NIH HHS
ID : U19 AI153217
Pays : United States
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