Nebulized hypertonic saline triggers nervous system-mediated active liquid secretion in cystic fibrosis swine trachea.
Administration, Inhalation
Animals
Animals, Genetically Modified
Bodily Secretions
/ drug effects
Cystic Fibrosis
/ drug therapy
Cystic Fibrosis Transmembrane Conductance Regulator
/ genetics
Female
Gene Knockout Techniques
Ion Transport
/ drug effects
Male
Mediastinal Cyst
/ drug therapy
Osmosis
/ drug effects
Respiratory Mucosa
/ drug effects
Saline Solution, Hypertonic
/ administration & dosage
Sensory Receptor Cells
/ drug effects
Swine
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
24 01 2019
24 01 2019
Historique:
received:
06
09
2018
accepted:
25
11
2018
entrez:
26
1
2019
pubmed:
27
1
2019
medline:
4
8
2020
Statut:
epublish
Résumé
Inhaled hypertonic saline (HTS) treatment is used to improve lung health in patients with cystic fibrosis (CF). The current consensus is that the treatment generates an osmotic gradient that draws water into the airways and increases airway surface liquid (ASL) volume. However, there is evidence that HTS may also stimulate active secretion of ASL by airway epithelia through the activation of sensory neurons. We tested the contribution of the nervous system and airway epithelia on HTS-stimulated ASL height increase in CF and wild-type swine airway. We used synchrotron-based imaging to investigate whether airway neurons and epithelia are involved in HTS treatment-triggered ASL secretion in CFTR
Identifiants
pubmed: 30679487
doi: 10.1038/s41598-018-36695-4
pii: 10.1038/s41598-018-36695-4
pmc: PMC6345831
doi:
Substances chimiques
Saline Solution, Hypertonic
0
Cystic Fibrosis Transmembrane Conductance Regulator
126880-72-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
540Subventions
Organisme : CIHR
ID : MOP-142410
Pays : Canada
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