Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy.
G-quadruplex
cancer therapy
oncogenes
selective ligands
telomere
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
24 Jan 2019
24 Jan 2019
Historique:
received:
03
12
2018
revised:
22
01
2019
accepted:
23
01
2019
entrez:
27
1
2019
pubmed:
27
1
2019
medline:
8
10
2019
Statut:
epublish
Résumé
A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-rich sequences, and has profound implications for various pharmacological and biological events, including cancers. Therefore, ligands interacting with G4s have attracted great attention as potential anticancer therapies or in molecular probe applications. To date, a large variety of DNA/RNA G4 ligands have been developed by a number of laboratories. As protein-targeting drugs face similar situations, G-quadruplex-interacting drugs displayed low selectivity to the targeted G-quadruplex structure. This low selectivity could cause unexpected effects that are usually reasons to halt the drug development process. In this review, we address the recent research on synthetic G4 DNA-interacting ligands that allow targeting of selected G4s as an approach toward the discovery of highly effective anticancer drugs.
Identifiants
pubmed: 30682877
pii: molecules24030429
doi: 10.3390/molecules24030429
pmc: PMC6384606
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Ligands
0
Molecular Probes
0
Guanine
5Z93L87A1R
DNA
9007-49-2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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