Role of cholesterol and sphingolipids in brain development and neurological diseases.
Cholesterol
Development
Nervous system
Neurological diseases
Sphingolipids
Journal
Lipids in health and disease
ISSN: 1476-511X
Titre abrégé: Lipids Health Dis
Pays: England
ID NLM: 101147696
Informations de publication
Date de publication:
25 Jan 2019
25 Jan 2019
Historique:
received:
19
07
2018
accepted:
06
01
2019
entrez:
27
1
2019
pubmed:
27
1
2019
medline:
29
5
2019
Statut:
epublish
Résumé
Brain is a vital organ of the human body which performs very important functions such as analysis, processing, coordination, and execution of electrical signals. For this purpose, it depends on a complex network of nerves which are ensheathed in lipids tailored myelin; an abundant source of lipids in the body. The nervous system is enriched with important classes of lipids; sphingolipids and cholesterol which compose the major portion of the brain particularly in the form of myelin. Both cholesterol and sphingolipids are embedded in the microdomains of membrane rafts and are functional units of the neuronal cell membrane. These molecules serve as the signaling molecules; hold important roles in the neuronal differentiation, synaptogenesis, and many others. Thus, their adequate provision and active metabolism are of crucial importance in the maintenance of physiological functions of brain and body of an individual. In the present review, we have highlighted the physiological roles of cholesterol and sphingolipids in the development of the nervous system as well as the association of their altered metabolism to neurological and neurodegenerative diseases.
Identifiants
pubmed: 30683111
doi: 10.1186/s12944-019-0965-z
pii: 10.1186/s12944-019-0965-z
pmc: PMC6347843
doi:
Substances chimiques
Lipids
0
Sphingolipids
0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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