Synthesis, spectroscopic characterization, molecular docking and theoretical studies (DFT) of N-(4-aminophenylsulfonyl)-2-(4-isobutylphenyl) propanamide having potential enzyme inhibition applications.
Administration, Oral
Amides
/ chemical synthesis
Animals
Anti-Inflammatory Agents
/ chemical synthesis
Binding Sites
Cyclooxygenase 1
/ chemistry
Cyclooxygenase 2
/ chemistry
Density Functional Theory
Enzyme Inhibitors
/ chemical synthesis
Free Radical Scavengers
/ chemistry
Ibuprofen
/ chemistry
Molecular Docking Simulation
Rats
Thermodynamics
Anti-inflammatory drugs
Antibiotics
AutoDock
DFT
Ibuprofen
Sulfanilamide
Journal
Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298
Informations de publication
Date de publication:
15 06 2019
15 06 2019
Historique:
received:
23
09
2018
revised:
17
12
2018
accepted:
15
01
2019
pubmed:
27
1
2019
medline:
9
9
2020
entrez:
27
1
2019
Statut:
ppublish
Résumé
A mutual prodrug (1) of ibuprofen and sulphanilamide has been synthesized with dual activity and improved toxicity profile. The synthesized compound has been characterized by elemental analysis, FT-IR,
Identifiants
pubmed: 30683553
pii: S0968-0896(18)31649-3
doi: 10.1016/j.bmc.2019.01.012
pii:
doi:
Substances chimiques
Amides
0
Anti-Inflammatory Agents
0
Enzyme Inhibitors
0
Free Radical Scavengers
0
Cyclooxygenase 1
EC 1.14.99.1
Cyclooxygenase 2
EC 1.14.99.1
Ibuprofen
WK2XYI10QM
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2397-2404Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.