Endothelial protein C receptor supports hematopoietic stem cell engraftment and expansion in Mpl-deficient mice.
Journal
Blood
ISSN: 1528-0020
Titre abrégé: Blood
Pays: United States
ID NLM: 7603509
Informations de publication
Date de publication:
28 03 2019
28 03 2019
Historique:
received:
09
03
2018
accepted:
15
01
2019
pubmed:
27
1
2019
medline:
4
12
2019
entrez:
27
1
2019
Statut:
ppublish
Résumé
Thrombopoietin (Thpo)/myeloproliferative leukemia virus oncogene (Mpl) signaling controls hematopoietic stem cell (HSC) self-renewal and quiescence; however, how these 2 seemingly opposing functions are controlled is not well understood. By transplantation of lentiviral-transduced hematopoietic cells in the Mpl-deficient mouse model, we addressed whether known or predicted Thpo target genes were able to rescue the Mpl-deficient phenotype of the mice. Among the tested genes, we identified endothelial protein C receptor (Epcr) to expand HSCs with the long-term (LT)-HSC surface phenotype in Mpl
Identifiants
pubmed: 30683655
pii: S0006-4971(20)42669-2
doi: 10.1182/blood-2018-03-837344
doi:
Substances chimiques
Endothelial Protein C Receptor
0
Mpl protein, mouse
0
Procr protein, mouse
0
Receptors, Thrombopoietin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1465-1478Informations de copyright
© 2019 by The American Society of Hematology.