Update of inflammatory proliferative retinopathy: Ischemia, hypoxia and angiogenesis.
CD40
CD40L
IL-1
Platelets
Proliferative retinopathy
Journal
Current research in translational medicine
ISSN: 2452-3186
Titre abrégé: Curr Res Transl Med
Pays: France
ID NLM: 101681234
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
09
04
2018
revised:
19
12
2018
accepted:
16
01
2019
pubmed:
28
1
2019
medline:
29
8
2020
entrez:
28
1
2019
Statut:
ppublish
Résumé
Diabetic retinopathy (DR) and retinopathy of prematurity (ROP) present two examples of proliferative retinopathy, characterized by the same stages of progression; ischemia of the retinal vessels, leads to hypoxia and to correct the problem there is the setting up of uncontrolled angiogenesis, which subsequently causes blindness or even detachment of the retina. The difference is the following; that DR initiated by the metabolic complications that are due to hyperglycemia, and ROP is induced by overexposure of the neonatal retina to oxygen. In this review, we will demonstrate the physiopathological mechanism of the two forms of proliferative retinopathy DR and ROP, in particular the role of the CD40/CD40L axis and IL-1 on vascular complications and onset of inflammation of the retina, the implications of their effects on the onset of pathogenic angiogenesis, thus understanding the link between platelets and retinal ischemia. In addition, what are the therapeutic targets that could slow its progression?
Identifiants
pubmed: 30685380
pii: S2452-3186(19)30005-4
doi: 10.1016/j.retram.2019.01.005
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
62-71Informations de copyright
Copyright © 2019 Elsevier Masson SAS. All rights reserved.