The effects of pinoresinol on cholinergic dysfunction-induced memory impairments and synaptic plasticity in mice.
Acetylcholinesterase
/ metabolism
Animals
Calcium
/ metabolism
Cell Line
Cholinesterase Inhibitors
/ therapeutic use
Cyclic AMP Response Element-Binding Protein
/ metabolism
Dementia
/ chemically induced
Extracellular Signal-Regulated MAP Kinases
/ metabolism
Furans
/ therapeutic use
Hippocampus
/ drug effects
Lignans
/ therapeutic use
Long-Term Potentiation
/ drug effects
Male
Memory Disorders
/ chemically induced
Mice, Inbred ICR
Neuronal Plasticity
/ drug effects
Proto-Oncogene Proteins c-akt
/ metabolism
Scopolamine
Alzheimer's disease
Memory
Pinoresinol
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
ISSN: 1873-6351
Titre abrégé: Food Chem Toxicol
Pays: England
ID NLM: 8207483
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
30
10
2018
revised:
02
01
2019
accepted:
17
01
2019
pubmed:
28
1
2019
medline:
2
4
2019
entrez:
28
1
2019
Statut:
ppublish
Résumé
Dementia is a category of brain diseases that cause a decrease in cognitive functions. Alzheimer's disease (AD) is the most frequently mentioned neurodegenerative disease showing dementia. Although many useful drugs for dementia were developed, we still need better and safer drugs. Here, we tested pinoresinol, a lignan found in sesame seed and olive oil, whether it could be a candidate for this purpose. Pinoresinol (25 mg/kg, p.o.) ameliorated memory impairment in dementia model induced by cholinergic blockade in the passive avoidance test in a dose-dependent manner. Moreover, pinoresinol (50 μM) facilitated induction of hippocampal long-term potentiation, a cellular model of learning and memory. Pinoresinol blocked acetylcholinesterase (AchE), an acetylcholine-degrading enzyme, activity in a concentration-dependent manner. Moreover, pinoresinol (50 μM) facilitated calcium influx into neuro2a cell. These results suggest that pinoresinol improves memory impairment and facilitates hippocampal LTP induction and these results might be related to the effect of pinoresinol on AChE and calcium influx.
Identifiants
pubmed: 30685474
pii: S0278-6915(19)30017-1
doi: 10.1016/j.fct.2019.01.017
pii:
doi:
Substances chimiques
Cholinesterase Inhibitors
0
Creb1 protein, mouse
0
Cyclic AMP Response Element-Binding Protein
0
Furans
0
Lignans
0
Scopolamine
DL48G20X8X
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Extracellular Signal-Regulated MAP Kinases
EC 2.7.11.24
Acetylcholinesterase
EC 3.1.1.7
Calcium
SY7Q814VUP
pinoresinol
V4N1UDY811
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
376-382Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.