The individual components of commercial isometamidium do not possess stronger trypanocidal activity than the mixture, nor bypass isometamidium resistance.

Chromatography Drug Resistance Phenanthridines / analysis Trypanocidal Agents / analysis Trypanosoma brucei brucei / drug effects Trypanosoma congolense / drug effects
Drug resistance Isometamidium Samorin Trypanosoma brucei brucei Trypanosoma congolense

Journal

International journal for parasitology. Drugs and drug resistance
ISSN: 2211-3207
Titre abrégé: Int J Parasitol Drugs Drug Resist
Pays: Netherlands
ID NLM: 101576715

Informations de publication

Date de publication:
04 2019
Historique:
received: 13 12 2018
revised: 17 01 2019
accepted: 20 01 2019
pubmed: 28 1 2019
medline: 22 11 2019
entrez: 28 1 2019
Statut: ppublish

Résumé

The four components present in the trypanocidal treatment Samorin, the commercially available formulation of isometamidium, were separated and purified by column chromatography. These compounds as well as the Samorin mixture and the other phenanthridine trypanocide, homidium, were tested on Trypanosoma congolense and wild type, diamidine- and isometamidium-resistant Trypanosoma brucei brucei strains using an Alamar blue drug sensitivity assay. EC

Identifiants

DOI: 10.1016/j.ijpddr.2019.01.003 PMID: 30685630 PMC: PMC6356087
pubmed: 30685630
pii: S2211-3207(18)30183-0
doi: 10.1016/j.ijpddr.2019.01.003
pmc: PMC6356087
pii:
doi:

Substances chimiques

Phenanthridines 0
Trypanocidal Agents 0
isometamidium chloride 7NH28I651F

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

54-58

Informations de copyright

Copyright © 2019. Published by Elsevier Ltd.

Références

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Auteurs

Anthonius A Eze (AA)

Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom; Medical Biochemistry Department, Faculty of Basic Medical Sciences, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Nigeria.

John Igoli (J)

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK; Department of Chemistry, College of Science, University of Agriculture, Makurdi, Nigeria.

Alexander I Gray (AI)

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.

Graham G Skellern (GG)

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.

Harry P De Koning (HP)

Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom. Electronic address: harry.de-koning@glasgow.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › The individual components of commercial...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › The individual components of commercial...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Phénanthridines › The individual components of commercial...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Trypanocides › The individual components of commercial...
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Trypanosoma › Trypanosoma brucei brucei › The individual components of commercial...
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Trypanosoma › Trypanosoma congolense › The individual components of commercial...