Donor characteristics do not influence transfusion-related acute lung injury incidence in a secondary analysis of two case-control studies.
Adolescent
Adult
Aged
Blood Donors
/ statistics & numerical data
Blood Group Antigens
/ adverse effects
Blood Transfusion
Case-Control Studies
Female
Humans
Incidence
Male
Middle Aged
Prospective Studies
Retrospective Studies
Risk Factors
Transfusion-Related Acute Lung Injury
/ epidemiology
Young Adult
Age
Blood type
Caractéristiques du donneur Âge
Donor characteristics
Groupe sanguin
Lésions pulmonaires aiguës liées à la transfusion
Sex
Sexe
Transfusion-related acute lung injury
Journal
Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine
ISSN: 1953-8022
Titre abrégé: Transfus Clin Biol
Pays: France
ID NLM: 9423846
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
03
04
2018
accepted:
25
05
2018
entrez:
29
1
2019
pubmed:
29
1
2019
medline:
9
5
2019
Statut:
ppublish
Résumé
To investigate the relation between donor characteristics and TRALI incidence. Transfusion-related acute lung injury (TRALI) is a potentially fatal complication of transfusion. In pre-clinical studies and several clinical studies, TRALI has been related to loss of product quality during red blood cell (RBC) storage, called the "storage lesion". Donor characteristics, as for example age, genetics and life style choices influence this "storage lesion". We hypothesized that donor sex, age and blood type is related to TRALI incidence. We performed a secondary analysis of two cohort studies, designed to identify TRALI risk factors by matching TRALI patients to transfused controls. We obtained donor sex, age and blood type from the Dutch Blood Bank Sanquin and investigated TRALI incidence in patients who were exposed to a certain donor characteristic. We used Kruskal-Wallis testing to compare the number of transfused products and Chi After implementation of the male-donor only plasma strategy, patients received more transfusion products from male donors. However, we did not detect a relation between TRALI incidence and donor sex. Both TRALI patients and transfused controls received mainly products from donors over 41 years old, but donor age did not influence TRALI risk. Donor blood type, the transfusion of blood type-compatible and blood type-matched products also had no influence on TRALI incidence. We conclude that in two cohorts of TRALI patients, donor age, donor sex and donor blood type are unrelated to TRALI.
Sections du résumé
OBJECTIVE
OBJECTIVE
To investigate the relation between donor characteristics and TRALI incidence.
BACKGROUND
BACKGROUND
Transfusion-related acute lung injury (TRALI) is a potentially fatal complication of transfusion. In pre-clinical studies and several clinical studies, TRALI has been related to loss of product quality during red blood cell (RBC) storage, called the "storage lesion". Donor characteristics, as for example age, genetics and life style choices influence this "storage lesion". We hypothesized that donor sex, age and blood type is related to TRALI incidence.
METHODS/MATERIALS
METHODS
We performed a secondary analysis of two cohort studies, designed to identify TRALI risk factors by matching TRALI patients to transfused controls. We obtained donor sex, age and blood type from the Dutch Blood Bank Sanquin and investigated TRALI incidence in patients who were exposed to a certain donor characteristic. We used Kruskal-Wallis testing to compare the number of transfused products and Chi
RESULTS
RESULTS
After implementation of the male-donor only plasma strategy, patients received more transfusion products from male donors. However, we did not detect a relation between TRALI incidence and donor sex. Both TRALI patients and transfused controls received mainly products from donors over 41 years old, but donor age did not influence TRALI risk. Donor blood type, the transfusion of blood type-compatible and blood type-matched products also had no influence on TRALI incidence.
CONCLUSION
CONCLUSIONS
We conclude that in two cohorts of TRALI patients, donor age, donor sex and donor blood type are unrelated to TRALI.
Identifiants
pubmed: 30686333
pii: S1246-7820(18)30057-0
doi: 10.1016/j.tracli.2018.05.003
pii:
doi:
Substances chimiques
Blood Group Antigens
0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
10-17Informations de copyright
Copyright © 2018 Elsevier Masson SAS. All rights reserved.