The release and activity of HMGB1 in ferroptosis.

Animals Autophagy Carbolines / pharmacology Cell Death Cell Line, Tumor Chloroquine / pharmacology Ferritins / metabolism Fibroblasts / metabolism HMGB1 Protein / metabolism Humans Immunity, Innate Inflammation Iron Overload Lipid Peroxidation Macrolides / pharmacology Mice Neoplasms Oximes / pharmacology Piperazines / pharmacology Sorafenib / pharmacology Sulfonamides / pharmacology Toll-Like Receptor 4 / metabolism
AGER Autophagy DAMP Ferroptosis HMGB1 Inflammation

Journal

Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516

Informations de publication

Date de publication:
05 03 2019
Historique:
received: 08 01 2019
accepted: 18 01 2019
pubmed: 29 1 2019
medline: 13 11 2019
entrez: 29 1 2019
Statut: ppublish

Résumé

Damage-associated molecular pattern molecules (DAMPs) are endogenous danger signals that alert the innate immune system and shape the inflammation response to cell death. However, the release and activity of DAMPs in ferroptosis, a recently identified form of regulated necrosis characterized by iron overload and lipid peroxidation, still remain poorly understood. Here, we demonstrate that HMGB1 is a DAMP released by ferroptotic cells in an autophagy-dependent manner. Both type I and II ferroptosis activators, including erastin, sorafenib, RSL3, and FIN56, induce HMGB1 release in cancer and noncancer cells. In contrast, genetic ablation (using ATG5

Identifiants

DOI: 10.1016/j.bbrc.2019.01.090 PMID: 30686534
pubmed: 30686534
pii: S0006-291X(19)30103-2
doi: 10.1016/j.bbrc.2019.01.090
pii:
doi:

Substances chimiques

Carbolines 0
FIN56 compound 0
HMGB1 Protein 0
HMGB1 protein, human 0
HMGB1 protein, mouse 0
Macrolides 0
Oximes 0
Piperazines 0
RSL3 compound 0
Sulfonamides 0
TLR4 protein, human 0
Toll-Like Receptor 4 0
erastin 0
Chloroquine 886U3H6UFF
bafilomycin A1 88899-55-2
Ferritins 9007-73-2
Sorafenib 9ZOQ3TZI87

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

278-283

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Qirong Wen (Q)

The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510510, China.

Jiao Liu (J)

The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510510, China.

Rui Kang (R)

Department of Surgery, UT Southwestern Medical Center, Dallas, TX 75390, USA.

Borong Zhou (B)

The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510510, China. Electronic address: zhoubr8@aliyun.com.

Daolin Tang (D)

Department of Surgery, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: daolin.tang@utsouthwestern.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The release and activity of HMGB1 in ferroptosis.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › The release and activity of HMGB1 in ferroptosis.
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Carbolines › The release and activity of HMGB1 in ferroptosis.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › The release and activity of HMGB1 in ferroptosis.
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › The release and activity of HMGB1 in ferroptosis.
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Aminoquinoléines › Chloroquine › The release and activity of HMGB1 in ferroptosis.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Métalloprotéines › Protéines de liaison au fer › Ferritines › The release and activity of HMGB1 in ferroptosis.
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › The release and activity of HMGB1 in ferroptosis.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines chromosomiques nonhistones › Protéines HMG › Protéines HMGB › Protéine HMGB1 › The release and activity of HMGB1 in ferroptosis.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The release and activity of HMGB1 in ferroptosis.
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › The release and activity of HMGB1 in ferroptosis.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › The release and activity of HMGB1 in ferroptosis.
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme du fer › Surcharge en fer › The release and activity of HMGB1 in ferroptosis.
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Peroxydation lipidique › The release and activity of HMGB1 in ferroptosis.
questionsmedicales.fr › Composés polycycliques › Composés macrocycliques › Polycétides › Macrolides › The release and activity of HMGB1 in ferroptosis.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The release and activity of HMGB1 in ferroptosis.
questionsmedicales.fr › Tumeurs › The release and activity of HMGB1 in ferroptosis.
questionsmedicales.fr › Composés chimiques organiques › Amines › Hydroxylamines › Oximes › The release and activity of HMGB1 in ferroptosis.
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipérazines › The release and activity of HMGB1 in ferroptosis.
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Acides nicotiniques › Nicotinamide › Sorafénib › The release and activity of HMGB1 in ferroptosis.
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfones › Sulfonamides › The release and activity of HMGB1 in ferroptosis.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs de reconnaissance de motifs moléculaires › Récepteurs de type Toll › Récepteur de type Toll-4 › The release and activity of HMGB1 in ferroptosis.