Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity.

Acetylcholinesterase / chemistry Catalytic Domain Cholinesterase Inhibitors / chemistry Coumarins / chemistry Enzyme Assays Humans Kinetics Molecular Docking Simulation Molecular Structure Monoamine Oxidase / chemistry Monoamine Oxidase Inhibitors / chemistry Protein Binding Structure-Activity Relationship
Human monoamine oxidase A Molecular docking Osthenol Selective competitive inhibitor

Journal

Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377

Informations de publication

Date de publication:
15 03 2019
Historique:
received: 26 11 2018
revised: 11 01 2019
accepted: 16 01 2019
pubmed: 29 1 2019
medline: 29 1 2020
entrez: 29 1 2019
Statut: ppublish

Résumé

Osthenol (6), a prenylated coumarin isolated from the dried roots of Angelica pubescens, potently and selectively inhibited recombinant human monoamine oxidase-A (hMAO-A) with an IC

Identifiants

DOI: 10.1016/j.bmcl.2019.01.016 PMID: 30686752
pubmed: 30686752
pii: S0960-894X(19)30026-5
doi: 10.1016/j.bmcl.2019.01.016
pii:
doi:

Substances chimiques

Cholinesterase Inhibitors 0
Coumarins 0
Monoamine Oxidase Inhibitors 0
osthenol 484-14-0
Monoamine Oxidase EC 1.4.3.4
monoamine oxidase A, human EC 1.4.3.4.
Acetylcholinesterase EC 3.1.1.7

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

839-843

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Seung Cheol Baek (SC)

Department of Pharmacy and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Republic of Korea.

Myung-Gyun Kang (MG)

Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea.

Ji-Eun Park (JE)

National Development Institute of Korean Medicine, Gyeongsan 38540, Republic of Korea.

Jae Pil Lee (JP)

Department of Pharmacy and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Republic of Korea.

Hanna Lee (H)

National Development Institute of Korean Medicine, Gyeongsan 38540, Republic of Korea.

Hyung Won Ryu (HW)

Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongju, Chungbuk 28116, Republic of Korea.

Chul Min Park (CM)

Center for Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.

Daeui Park (D)

Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea; Center for Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.

Myoung-Lae Cho (ML)

National Development Institute of Korean Medicine, Gyeongsan 38540, Republic of Korea.

Sei-Ryang Oh (SR)

Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongju, Chungbuk 28116, Republic of Korea.

Hoon Kim (H)

Department of Pharmacy and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Republic of Korea. Electronic address: hoon@sunchon.ac.kr.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Acetylcholinesterase › Osthenol, a prenylated coumarin, as a...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Domaine catalytique › Osthenol, a prenylated coumarin, as a...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Anticholinestérasiques › Osthenol, a prenylated coumarin, as a...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › Coumarines › Osthenol, a prenylated coumarin, as a...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Dosages enzymatiques › Osthenol, a prenylated coumarin, as a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Osthenol, a prenylated coumarin, as a...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › Osthenol, a prenylated coumarin, as a...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Osthenol, a prenylated coumarin, as a...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Osthenol, a prenylated coumarin, as a...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH2 group donors › Monoamine oxidase › Osthenol, a prenylated coumarin, as a...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de la monoamine oxydase › Osthenol, a prenylated coumarin, as a...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Osthenol, a prenylated coumarin, as a...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Osthenol, a prenylated coumarin, as a...