Central Mechanisms of Glucose Sensing and Counterregulation in Defense of Hypoglycemia.
Journal
Endocrine reviews
ISSN: 1945-7189
Titre abrégé: Endocr Rev
Pays: United States
ID NLM: 8006258
Informations de publication
Date de publication:
01 06 2019
01 06 2019
Historique:
received:
07
09
2018
accepted:
17
01
2019
pubmed:
29
1
2019
medline:
10
1
2020
entrez:
29
1
2019
Statut:
ppublish
Résumé
Glucose homeostasis requires an organism to rapidly respond to changes in plasma glucose concentrations. Iatrogenic hypoglycemia as a result of treatment with insulin or sulfonylureas is the most common cause of hypoglycemia in humans and is generally only seen in patients with diabetes who take these medications. The first response to a fall in glucose is the detection of impending hypoglycemia by hypoglycemia-detecting sensors, including glucose-sensing neurons in the hypothalamus and other regions. This detection is then linked to a series of neural and hormonal responses that serve to prevent the fall in blood glucose and restore euglycemia. In this review, we discuss the current state of knowledge about central glucose sensing and how detection of a fall in glucose leads to the stimulation of counterregulatory hormone and behavior responses. We also review how diabetes and recurrent hypoglycemia impact glucose sensing and counterregulation, leading to development of impaired awareness of hypoglycemia in diabetes.
Identifiants
pubmed: 30689785
pii: 5297093
doi: 10.1210/er.2018-00226
pmc: PMC6505456
doi:
Substances chimiques
Blood Glucose
0
Hypoglycemic Agents
0
Insulin
0
Sulfonylurea Compounds
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
768-788Subventions
Organisme : NINDS NIH HHS
ID : R01 NS097184
Pays : United States
Organisme : NIH HHS
ID : OT2 OD024912
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS035192
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020541
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH105941
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007203
Pays : United States
Informations de copyright
Copyright © 2019 Endocrine Society.
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