Impairment of Inhibition of Trigeminal Nociception via Conditioned Pain Modulation in Persons with Migraine Headaches.
Adolescent
Adult
Blinking
/ physiology
Case-Control Studies
Catastrophization
Conditioning, Psychological
/ physiology
Depression
Female
Forearm
/ blood supply
Humans
Ischemia
/ physiopathology
Male
Migraine Disorders
/ physiopathology
Nociception
/ physiology
Pain
/ physiopathology
Pain Measurement
Pain Threshold
/ physiology
Trigeminal Nerve
/ physiopathology
Young Adult
Conditioned Pain Modulation
Migraine Headaches
Nociceptive Blink Reflex
Pain Modulation
Journal
Pain medicine (Malden, Mass.)
ISSN: 1526-4637
Titre abrégé: Pain Med
Pays: England
ID NLM: 100894201
Informations de publication
Date de publication:
01 08 2019
01 08 2019
Historique:
pubmed:
29
1
2019
medline:
25
8
2020
entrez:
29
1
2019
Statut:
ppublish
Résumé
To assess conditioned pain modulation efficiency in persons with and without migraine headaches. Cross-sectional assessment of experimental pain. University campus and surrounding community in a large Midwestern US city. Twenty-three adults with and 32 without a history of migraine headaches participated in the study. Participants were mostly female (N = 40) with an average age of 23 years. Four electrocutaneous stimulations of the supraorbital branch of the left trigeminal nerve were delivered at 150% of an individually determined pain threshold. Conditioned pain modulation was assessed by applying a noxious counterstimulus (forearm ischemia) and delivering four more electrocutaneous stimulations. After each stimulation, pain and the nociceptive blink reflex were assessed. Depression and pain catastrophizing were assessed to control for the potential influence of these variables on pain modulation. Participants with and without migraine headaches had similar baseline pain responsivity, without significant differences in pain report or nociceptive blink reflexes. Pain report was inhibited by conditioned pain modulation in both the migraine and control groups. However, unlike nonmigraine controls, participants with migraines did not exhibit an inhibition of nociceptive blink reflexes during the ischemia task. This pattern persisted after controlling for level of pain catastrophizing and depression. Migraine sufferers exhibited impaired conditioned pain modulation of the nociceptive blink reflex, suggesting a deficiency in inhibition of trigeminal nociception, which may contribute to the development of migraine headaches.
Identifiants
pubmed: 30690591
pii: 5301760
doi: 10.1093/pm/pny305
pmc: PMC7963204
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1600-1610Subventions
Organisme : NIA NIH HHS
ID : K99 AG052642
Pays : United States
Organisme : NIA NIH HHS
ID : R00 AG052642
Pays : United States
Organisme : NIMHD NIH HHS
ID : R01 MD007807
Pays : United States
Informations de copyright
© 2019 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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