Moderate Physical Activity as a Prevention Method for Knee Osteoarthritis and the Role of Synoviocytes as Biological Key.
Animals
Anterior Cruciate Ligament Injuries
/ complications
Cytokines
/ metabolism
Disease Models, Animal
Interleukin-10
/ metabolism
Interleukin-1beta
/ metabolism
Interleukin-4
/ metabolism
Interleukin-6
/ metabolism
Male
Osteoarthritis, Knee
/ metabolism
Physical Conditioning, Animal
/ methods
Rats
Synoviocytes
/ metabolism
Transcription Factors
/ metabolism
Tumor Necrosis Factor-alpha
/ metabolism
interleukins
lubricin
osteoarthritis
physical activity
synovium
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 01 2019
25 01 2019
Historique:
received:
23
12
2018
revised:
22
01
2019
accepted:
23
01
2019
entrez:
30
1
2019
pubmed:
30
1
2019
medline:
5
6
2019
Statut:
epublish
Résumé
The purpose of this study was to investigate the influence of moderate physical activity (MPA) on the expression of osteoarthritis (OA)-related (IL-1β, IL-6, TNF-α, MMP-13) and anti-inflammatory and chondroprotective (IL-4, IL-10, lubricin) biomarkers in the synovium of an OA-induced rat model. A total of 32 rats were divided into four groups: Control rats (Group 1); rats performing MPA (Group 2); anterior cruciate ligament transection (ACLT)-rats with OA (Group 3); and, ACLT-rats performing MPA (Group 4). Analyses were performed using Hematoxylin & Eosin (H & E) staining, histomorphometry and immunohistochemistry. In Group 3, OA biomarkers were significantly increased, whereas, IL-4, IL-10, and lubricin were significantly lower than in the other experimental groups. We hypothesize that MPA might partake in rescuing type B synoviocyte dysfunction at the early stages of OA, delaying the progression of the disease.
Identifiants
pubmed: 30691048
pii: ijms20030511
doi: 10.3390/ijms20030511
pmc: PMC6387266
pii:
doi:
Substances chimiques
Cytokines
0
IL1B protein, rat
0
Il6 protein, rat
0
Interleukin-1beta
0
Interleukin-6
0
Rabep2 protein, rat
0
Transcription Factors
0
Tumor Necrosis Factor-alpha
0
Interleukin-10
130068-27-8
Interleukin-4
207137-56-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : University Research Project Grant, University of Catania- BIOMETEC
ID : Triennial Research Plan 2016-2018
Pays : International
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