The circular RNome of primary breast cancer.
Journal
Genome research
ISSN: 1549-5469
Titre abrégé: Genome Res
Pays: United States
ID NLM: 9518021
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
05
04
2018
accepted:
23
01
2019
pubmed:
30
1
2019
medline:
14
6
2019
entrez:
30
1
2019
Statut:
ppublish
Résumé
Circular RNAs (circRNAs) are a class of RNAs that is under increasing scrutiny, although their functional roles are debated. We analyzed RNA-seq data of 348 primary breast cancers and developed a method to identify circRNAs that does not rely on unmapped reads or known splice junctions. We identified 95,843 circRNAs, of which 20,441 were found recurrently. Of the circRNAs that match exon boundaries of the same gene, 668 showed a poor or even negative (
Identifiants
pubmed: 30692147
pii: gr.238121.118
doi: 10.1101/gr.238121.118
pmc: PMC6396421
doi:
Substances chimiques
Biomarkers, Tumor
0
CNOT2 protein, human
0
Carrier Proteins
0
RERE protein, human
0
RNA, Circular
0
Repressor Proteins
0
RNA
63231-63-0
CREB-Binding Protein
EC 2.3.1.48
CREBBP protein, human
EC 2.3.1.48
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
356-366Subventions
Organisme : NCI NIH HHS
ID : P50 CA168504
Pays : United States
Organisme : Wellcome Trust
ID : WT100183MA
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : Wellcome Trust
ID : 077012/Z/05/Z
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2019 Smid et al.; Published by Cold Spring Harbor Laboratory Press.
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