The metabolite repair enzyme Nit1 is a dual-targeted amidase that disposes of damaged glutathione in

Amidohydrolases / genetics Aminohydrolases / genetics Arabidopsis / enzymology Arabidopsis Proteins / genetics Cytoplasm / enzymology Glutathione / metabolism Plastids / enzymology
Nit1 proteins glutathione glutathione damage metabolite damage metabolite repair

Journal

The Biochemical journal
ISSN: 1470-8728
Titre abrégé: Biochem J
Pays: England
ID NLM: 2984726R

Informations de publication

Date de publication:
19 02 2019
Historique:
received: 09 12 2018
revised: 16 01 2019
accepted: 28 01 2019
pubmed: 30 1 2019
medline: 19 12 2019
entrez: 30 1 2019
Statut: epublish

Résumé

The tripeptide glutathione (GSH) is implicated in various crucial physiological processes including redox buffering and protection against heavy metal toxicity. GSH is abundant in plants, with reported intracellular concentrations typically in the 1-10 mM range. Various aminotransferases can inadvertently transaminate the amino group of the γ-glutamyl moiety of GSH to produce deaminated glutathione (dGSH), a metabolite damage product. It was recently reported that an amidase known as Nit1 participates in dGSH breakdown in mammals and yeast. Plants have a hitherto uncharacterized homolog of the Nit1 amidase. We show that recombinant

Identifiants

DOI: 10.1042/BCJ20180931 PMID: 30692244
pubmed: 30692244
pii: BCJ20180931
doi: 10.1042/BCJ20180931
doi:

Substances chimiques

Arabidopsis Proteins 0
Amidohydrolases EC 3.5.-
amidase EC 3.5.1.4
Aminohydrolases EC 3.5.4.-
nitrilase EC 3.5.5.1
Glutathione GAN16C9B8O

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

683-697

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

Auteurs

Thomas D Niehaus (TD)

Department of Plant and Microbial Biology, University of Minnesota, Saint Paul, MN, U.S.A. tniehaus@umn.edu.
ORCID: 0000-0002-3575-8001

Jenelle A Patterson (JA)

Department of Horticultural Sciences, University of Florida, Gainesville, FL, U.S.A.

Danny C Alexander (DC)

Metabolon Inc., Morrisville, NC, U.S.A.

Jakob S Folz (JS)

West Coast Metabolomics Center, University of California Davis, Davis, CA, U.S.A.

Michal Pyc (M)

Department of Botany, University of British Colombia, Vancouver, British Columbia, Canada.

Brian S MacTavish (BS)

Chemistry Department, University of Florida, Gainesville, FL, U.S.A.

Steven D Bruner (SD)

Chemistry Department, University of Florida, Gainesville, FL, U.S.A.

Robert T Mullen (RT)

Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.

Oliver Fiehn (O)

West Coast Metabolomics Center, University of California Davis, Davis, CA, U.S.A.

Andrew D Hanson (AD)

Department of Horticultural Sciences, University of Florida, Gainesville, FL, U.S.A.
ORCID: 0000-0003-2585-9340

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › The metabolite repair enzyme Nit1 is a...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Aminohydrolases › The metabolite repair enzyme Nit1 is a...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Brassicaceae › Arabidopsis › The metabolite repair enzyme Nit1 is a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines végétales › Protéines d'Arabidopsis › The metabolite repair enzyme Nit1 is a...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › The metabolite repair enzyme Nit1 is a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Oligopeptides › Glutathion › The metabolite repair enzyme Nit1 is a...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Plastes › The metabolite repair enzyme Nit1 is a...