A two-stage estimation procedure for non-linear structural equation models.

Latent variable Neuroimaging Non-linear estimation Two-stage estimator

Journal

Biostatistics (Oxford, England)
ISSN: 1468-4357
Titre abrégé: Biostatistics
Pays: England
ID NLM: 100897327

Informations de publication

Date de publication:
01 10 2020
Historique:
received: 08 12 2017
revised: 21 10 2018
accepted: 28 10 2018
pubmed: 31 1 2019
medline: 26 11 2021
entrez: 31 1 2019
Statut: ppublish

Résumé

Applications of structural equation models (SEMs) are often restricted to linear associations between variables. Maximum likelihood (ML) estimation in non-linear models may be complex and require numerical integration. Furthermore, ML inference is sensitive to distributional assumptions. In this article, we introduce a simple two-stage estimation technique for estimation of non-linear associations between latent variables. Here both steps are based on fitting linear SEMs: first a linear model is fitted to data on the latent predictor and terms describing the non-linear effect are predicted by their conditional means. In the second step, the predictions are included in a linear model for the latent outcome variable. We show that this procedure is consistent and identifies its asymptotic distribution. We also illustrate how this framework easily allows the association between latent variables to be modeled using restricted cubic splines, and we develop a modified estimator which is robust to non-normality of the latent predictor. In a simulation study, we compare the proposed method to MLE and alternative two-stage estimation techniques.

Identifiants

pubmed: 30698649
pii: 5304080
doi: 10.1093/biostatistics/kxy082
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

676-691

Informations de copyright

© The Author 2019. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Auteurs

Klaus Kähler Holst (KK)

Department of Biostatistics, University of Copenhagen, Øster Farimagsgade 5, entr. B, P.O.Box 2099, DK-1014 Copenhagen K, Denmark, Neurobiology Research Unit, Rigshospitalet, Copenhagen University Hospital, Juliane Maries Vej 28, building 6931, 3rd floor, DK-2100 Copenhagen, Denmark, and Maersk, Esplanaden 50, DK-1098 Copenhagen K, Denmark.

Esben Budtz-Jørgensen (E)

Department of Biostatistics, University of Copenhagen. Øster Farimagsgade 5, entr. B, P.O.Box 2099, DK-1014 Copenhagen K, Denmark.

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