Could Dietary Glutamate Play a Role in Psychiatric Distress?


Journal

Neuropsychobiology
ISSN: 1423-0224
Titre abrégé: Neuropsychobiology
Pays: Switzerland
ID NLM: 7512895

Informations de publication

Date de publication:
2020
Historique:
received: 30 06 2018
accepted: 18 12 2018
pubmed: 31 1 2019
medline: 13 11 2020
entrez: 31 1 2019
Statut: ppublish

Résumé

Glutamate is an amino acid that functions as an excitatory neurotransmitter. It has also been associated with somatic and psychiatric distress and is implicated in the pathophysiology of psychiatric disorders such as schizophrenia. Ingestion of dietary glutamate, such as monosodium glutamate (MSG), has been mechanistically linked with greater distress among patients with chronic pain conditions, though findings have been equivocal. Preliminary research suggests that an MSG-restricted diet confers beneficial effects on somatic symptoms and well-being for some individuals with chronic pain conditions. In addition to associations with somatic distress, glutamate has been associated with the onset and progression of psychiatric symptoms. Thus, the role of dietary glutamate in psychiatric distress represents an underdeveloped and potentially important area for future research aimed at clarifying pathophysiological mechanisms and identifying targets for dietary intervention in psychiatric illnesses.

Identifiants

pubmed: 30699435
pii: 000496294
doi: 10.1159/000496294
pmc: PMC6667320
mid: NIHMS1006002
doi:

Substances chimiques

Excitatory Amino Acid Agents 0
Flavoring Agents 0
Glutamates 0
Sodium Glutamate W81N5U6R6U

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

13-19

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH082784
Pays : United States

Informations de copyright

© 2019 S. Karger AG, Basel.

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Auteurs

A Zarina Kraal (AZ)

Department of Psychology, University of Michigan, Ann Arbor, Michigan, USA.
College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA.

Nicole R Arvanitis (NR)

College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA.

Andrew P Jaeger (AP)

College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA.

Vicki L Ellingrod (VL)

Department of Psychology, University of Michigan, Ann Arbor, Michigan, USA, vellingr@med.umich.edu.
College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA, vellingr@med.umich.edu.

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