Gray and white matter differences in adolescents and young adults with prior suicide attempts across bipolar and major depressive disorders.
Adolescent
Adult
Anisotropy
Bipolar Disorder
/ diagnostic imaging
Brain
/ diagnostic imaging
Case-Control Studies
Depressive Disorder, Major
/ diagnostic imaging
Diffusion Magnetic Resonance Imaging
Female
Gray Matter
/ diagnostic imaging
Hippocampus
/ diagnostic imaging
Humans
Magnetic Resonance Imaging
Male
Organ Size
Prefrontal Cortex
/ diagnostic imaging
Suicide, Attempted
White Matter
/ diagnostic imaging
Young Adult
Adolescent
Diffusion tensor imaging
Frontal Lobe
Magnetic resonance imaging
Suicide
Young Adult
Journal
Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073
Informations de publication
Date de publication:
15 02 2019
15 02 2019
Historique:
received:
02
07
2018
revised:
24
09
2018
accepted:
17
11
2018
entrez:
1
2
2019
pubmed:
1
2
2019
medline:
4
4
2019
Statut:
ppublish
Résumé
Findings regarding brain circuitry abnormalities in suicide attempters (SAs) converge across bipolar disorder (BD) and major depressive disorder (MDD), the most common disorders observed in suicides. These abnormalities appear to be present during adolescence/young adulthood when suicide rates increase steeply, and suicide is a leading cause of death in this age group. Identification of brain circuitry common to adolescent/young adult SAs with BD and MDD is important for generating widely effective early prevention strategies. We examined brain circuitry in SAs in adolescents/young adults across these two disorders. Eighty-three participants (ages 14-25 years), 46 with BD (21 SAs) and 37 with MDD (19 SAs), underwent structural and diffusion-weighted magnetic resonance scanning. Whole-brain analyses compared gray matter (GM) volume and white matter (WM) fractional anisotropy (FA) between SAs and non-suicide attempters (NSAs) across and within BD and MDD (p < 0.005). Across and within BD and MDD, SAs showed differences compared to NSAs in ventral prefrontal cortex (PFC) GM volume and fronto-limbic (including uncinate fasciculus (UF)) WM FA. Exploratory analyses showed additional within-disorder differences for BD SAs in dorsolateral PFC (dlPFC) and hippocampus GM volume and UF FA, and for MDD SAs dorsomedial and dlPFC GM and dorsal frontal WM. However, there was no significant interaction between suicide attempt status and diagnosis. Modest sample size. Common fronto-limbic gray and white matter alterations in adolescent/young adult SAs are potential targets for suicide prevention strategies across mood disorders. Preliminary findings of disorder-specific regional findings could suggest diagnostic-specific optimal targets may exist.
Sections du résumé
BACKGROUND
Findings regarding brain circuitry abnormalities in suicide attempters (SAs) converge across bipolar disorder (BD) and major depressive disorder (MDD), the most common disorders observed in suicides. These abnormalities appear to be present during adolescence/young adulthood when suicide rates increase steeply, and suicide is a leading cause of death in this age group. Identification of brain circuitry common to adolescent/young adult SAs with BD and MDD is important for generating widely effective early prevention strategies. We examined brain circuitry in SAs in adolescents/young adults across these two disorders.
METHODS
Eighty-three participants (ages 14-25 years), 46 with BD (21 SAs) and 37 with MDD (19 SAs), underwent structural and diffusion-weighted magnetic resonance scanning. Whole-brain analyses compared gray matter (GM) volume and white matter (WM) fractional anisotropy (FA) between SAs and non-suicide attempters (NSAs) across and within BD and MDD (p < 0.005).
RESULTS
Across and within BD and MDD, SAs showed differences compared to NSAs in ventral prefrontal cortex (PFC) GM volume and fronto-limbic (including uncinate fasciculus (UF)) WM FA. Exploratory analyses showed additional within-disorder differences for BD SAs in dorsolateral PFC (dlPFC) and hippocampus GM volume and UF FA, and for MDD SAs dorsomedial and dlPFC GM and dorsal frontal WM. However, there was no significant interaction between suicide attempt status and diagnosis.
LIMITATIONS
Modest sample size.
CONCLUSIONS
Common fronto-limbic gray and white matter alterations in adolescent/young adult SAs are potential targets for suicide prevention strategies across mood disorders. Preliminary findings of disorder-specific regional findings could suggest diagnostic-specific optimal targets may exist.
Identifiants
pubmed: 30699851
pii: S0165-0327(17)32639-3
doi: 10.1016/j.jad.2018.11.095
pmc: PMC6903411
mid: NIHMS1543562
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1089-1097Subventions
Organisme : NIDA NIH HHS
ID : T32 DA022975
Pays : United States
Organisme : NIMH NIH HHS
ID : RC1 MH088366
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH014276
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000142
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH069747
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH070902
Pays : United States
Informations de copyright
Copyright © 2018. Published by Elsevier B.V.
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