Design, Synthesis, Docking Studies and Monoamine Oxidase Inhibition of a Small Library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazoles.

Enzyme Activation / drug effects Models, Molecular Monoamine Oxidase / metabolism Monoamine Oxidase Inhibitors / chemical synthesis Pyrazoles / chemical synthesis Stereoisomerism Structure-Activity Relationship
enantioseparation molecular modelling monoamine oxidase prenyl pyrazoline

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
29 Jan 2019
Historique:
received: 28 12 2018
revised: 24 01 2019
accepted: 27 01 2019
entrez: 1 2 2019
pubmed: 1 2 2019
medline: 14 6 2019
Statut: epublish

Résumé

New

Identifiants

DOI: 10.3390/molecules24030484 PMID: 30700029 PMC: PMC6384781
pubmed: 30700029
pii: molecules24030484
doi: 10.3390/molecules24030484
pmc: PMC6384781
pii:
doi:

Substances chimiques

Monoamine Oxidase Inhibitors 0
Pyrazoles 0
Monoamine Oxidase EC 1.4.3.4

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Déclaration de conflit d'intérêts

The authors declare no competing financial interests.

Références

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Auteurs

Paolo Guglielmi (P)

Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy. paolo.guglielmi@uniroma1.it.

Simone Carradori (S)

Department of Pharmacy, "G. D'Annunzio" University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy. simone.carradori@unich.it.

Giulio Poli (G)

Department of Pharmacy, Università di Pisa, via Bonanno 6, 56126 Pisa, Italy. giulio.poli@unipi.it.

Daniela Secci (D)

Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy. daniela.secci@uniroma1.it.

Roberto Cirilli (R)

Centro nazionale per il controllo e la valutazione dei farmaci, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. roberto.cirilli@iss.it.

Giulia Rotondi (G)

Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy. giulia.rotondi@uniroma1.it.

Paola Chimenti (P)

Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy. paola.chimenti@uniroma1.it.

Anél Petzer (A)

Pharmaceutical Chemistry, School of Pharmacy and Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom 2520, South Africa. 12264954@nwu.ac.za.

Jacobus P Petzer (JP)

Pharmaceutical Chemistry, School of Pharmacy and Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom 2520, South Africa. jacques.petzer@nwu.ac.za.

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Activation enzymatique › Design, Synthesis, Docking Studies and...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Design, Synthesis, Docking Studies and...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH2 group donors › Monoamine oxidase › Design, Synthesis, Docking Studies and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de la monoamine oxydase › Design, Synthesis, Docking Studies and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Pyrazoles › Design, Synthesis, Docking Studies and...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes de chimie organique › Isomérie › Stéréoisomérie › Design, Synthesis, Docking Studies and...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Design, Synthesis, Docking Studies and...