Critical Role of SREBP-1c Large-VLDL Pathway in Environment-Induced Hypertriglyceridemia of Apo AV Deficiency.
Aging
/ metabolism
Animal Feed
/ adverse effects
Animals
Apolipoprotein A-V
/ deficiency
Apolipoproteins
/ blood
Chylomicrons
/ metabolism
Female
Fructose
/ toxicity
Gene Expression Regulation
/ drug effects
Gene-Environment Interaction
Humans
Hydrocarbons, Fluorinated
/ pharmacology
Hypertriglyceridemia
/ blood
Lipids
/ blood
Lipoproteins, VLDL
/ biosynthesis
Liver X Receptors
/ agonists
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Models, Animal
Olive Oil
/ toxicity
Sterol Regulatory Element Binding Protein 1
/ deficiency
Sulfonamides
/ pharmacology
carbohydrate
diet
hypertriglyceridemia
phenotype
sterol regulatory element-binding protein
Journal
Arteriosclerosis, thrombosis, and vascular biology
ISSN: 1524-4636
Titre abrégé: Arterioscler Thromb Vasc Biol
Pays: United States
ID NLM: 9505803
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
pubmed:
1
2
2019
medline:
14
1
2020
entrez:
1
2
2019
Statut:
ppublish
Résumé
Objective- APOA5 variants are strongly associated with hypertriglyceridemia, as well as increased risks of cardiovascular disease and acute pancreatitis. Hypertriglyceridemia in apo AV dysfunction often aggravates by environmental factors such as high-carbohydrate diets or aging. To date, the molecular mechanisms by which these environmental factors induce hypertriglyceridemia are poorly defined, leaving the high-risk hypertriglyceridemia condition undertreated. Previously, we reported that LXR (liver X receptor)-SREBP (sterol regulatory element-binding protein)-1c pathway regulates large-VLDL (very low-density lipoprotein) production induced by LXR agonist. However, the pathophysiological relevance of the finding remains unknown. Approach and Results- Here, we reconstitute the environment-induced hypertriglyceridemia phenotype of human APOA5 deficiency in Apoa5
Identifiants
pubmed: 30700132
doi: 10.1161/ATVBAHA.118.311931
pmc: PMC6399473
mid: NIHMS1519313
doi:
Substances chimiques
Apolipoprotein A-V
0
Apolipoproteins
0
Chylomicrons
0
Hydrocarbons, Fluorinated
0
Lipids
0
Lipoproteins, VLDL
0
Liver X Receptors
0
Olive Oil
0
Sterol Regulatory Element Binding Protein 1
0
Sulfonamides
0
T0901317
0
Fructose
30237-26-4
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
373-386Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL020948
Pays : United States
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