Ingestible hydrogel device.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
30 01 2019
30 01 2019
Historique:
received:
04
09
2018
accepted:
20
12
2018
entrez:
1
2
2019
pubmed:
1
2
2019
medline:
9
4
2019
Statut:
epublish
Résumé
Devices that interact with living organisms are typically made of metals, silicon, ceramics, and plastics. Implantation of such devices for long-term monitoring or treatment generally requires invasive procedures. Hydrogels offer new opportunities for human-machine interactions due to their superior mechanical compliance and biocompatibility. Additionally, oral administration, coupled with gastric residency, serves as a non-invasive alternative to implantation. Achieving gastric residency with hydrogels requires the hydrogels to swell very rapidly and to withstand gastric mechanical forces over time. However, high swelling ratio, high swelling speed, and long-term robustness do not coexist in existing hydrogels. Here, we introduce a hydrogel device that can be ingested as a standard-sized pill, swell rapidly into a large soft sphere, and maintain robustness under repeated mechanical loads in the stomach for up to one month. Large animal tests support the exceptional performance of the ingestible hydrogel device for long-term gastric retention and physiological monitoring.
Identifiants
pubmed: 30700712
doi: 10.1038/s41467-019-08355-2
pii: 10.1038/s41467-019-08355-2
pmc: PMC6353937
doi:
Substances chimiques
Hydrogels
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
493Subventions
Organisme : NIBIB NIH HHS
ID : R01 EB000244
Pays : United States
Organisme : NIBIB NIH HHS
ID : R37 EB000244
Pays : United States
Organisme : NIH HHS
ID : EB000244
Pays : United States
Références
Am J Gastroenterol. 2006 Oct;101(10):2218-22
pubmed: 16848804
Biomaterials. 2003 Nov;24(24):4337-51
pubmed: 12922147
Am J Dig Dis. 1969 Sep;14(9):611-8
pubmed: 5810776
Obes Surg. 2010 Sep;20(9):1227-30
pubmed: 19082675
Am J Clin Nutr. 1996 Mar;63(3):354-7
pubmed: 8602592
Sci Transl Med. 2016 Nov 16;8(365):365ra157
pubmed: 27856796
Soft Matter. 2016 Oct 4;12(39):8069-8086
pubmed: 27714361
Tissue Eng Part B Rev. 2011 Jun;17(3):155-64
pubmed: 21303220
J Exp Biol. 2004 Jul;207(Pt 15):2715-24
pubmed: 15201304
Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2200-2205
pubmed: 28202725
Lancet. 1982 Jan 23;1(8265):198-9
pubmed: 6119560
Adv Mater. 2016 Dec;28(46):10244-10249
pubmed: 27714887
J Control Release. 2006 Jul 20;113(3):208-15
pubmed: 16806558
Nature. 2018 May;557(7703):86-91
pubmed: 29720635
Am J Surg. 1972 Sep;124(3):331-3
pubmed: 5056893
J Control Release. 2004 Jan 8;94(1):143-53
pubmed: 14684278
Nat Commun. 2017 Jul 25;8(1):124
pubmed: 28743858
PLoS One. 2014 Feb 26;9(2):e90329
pubmed: 24587327
Pharm Res. 1989 Jun;6(6):506-9
pubmed: 2762227
J Control Release. 2000 Feb 3;63(3):235-59
pubmed: 10601721
Soft Matter. 2017 Oct 4;13(38):6852-6857
pubmed: 28837202
Science. 2018 May 25;360(6391):915-918
pubmed: 29798884
Chem Soc Rev. 2019 Mar 18;48(6):1642-1667
pubmed: 30474663
J Biomed Mater Res. 1999 Jan;44(1):53-62
pubmed: 10397904
Adv Healthc Mater. 2017 Oct;6(19):
pubmed: 28714269
Gastroenterology. 1988 Jun;94(6):1276-84
pubmed: 3360255
Physiol Behav. 1994 Aug;56(2):311-7
pubmed: 7938243
J Control Release. 2000 Feb 14;64(1-3):39-51
pubmed: 10640644
Nat Commun. 2017 Feb 01;8:14230
pubmed: 28145412
Trends Biotechnol. 2015 Oct;33(10):575-585
pubmed: 26403162
Adv Mater. 2016 Jun;28(22):4497-505
pubmed: 26639322
Nat Mater. 2018 Sep;17(9):834-842
pubmed: 29891893
J Pharm Sci. 2015 Sep;104(9):2855-63
pubmed: 25411065
Nat Mater. 2015 Oct;14(10):1065-71
pubmed: 26213897