Interleukin-22 protects intestinal stem cells against genotoxic stress.

Animals Apoptosis / drug effects Cell Transformation, Neoplastic / drug effects Colon / cytology Colonic Neoplasms / genetics DNA Damage Diet / adverse effects Glucosinolates / administration & dosage Immunity, Innate Interleukins / biosynthesis Intestinal Mucosa / cytology Ligands Mice Mutagens / administration & dosage Mutation / genetics Receptors, Aryl Hydrocarbon / metabolism Receptors, Interleukin / metabolism Stem Cells / cytology T-Lymphocytes / metabolism Interleukin-22

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
02 2019
Historique:
received: 29 04 2018
accepted: 02 01 2019
pubmed: 1 2 2019
medline: 25 7 2019
entrez: 1 2 2019
Statut: ppublish

Résumé

Environmental genotoxic factors pose a challenge to the genomic integrity of epithelial cells at barrier surfaces that separate host organisms from the environment. They can induce mutations that, if they occur in epithelial stem cells, contribute to malignant transformation and cancer development

Identifiants

DOI: 10.1038/s41586-019-0899-7 PMID: 30700914 PMC: PMC6420091
pubmed: 30700914
doi: 10.1038/s41586-019-0899-7
pii: 10.1038/s41586-019-0899-7
pmc: PMC6420091
mid: EMS81063
doi:

Substances chimiques

Glucosinolates 0
Interleukins 0
Ligands 0
Mutagens 0
Receptors, Aryl Hydrocarbon 0
Receptors, Interleukin 0
interleukin-22 receptor 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Pagination

249-253

Commentaires et corrections

Type : CommentIn

Références

Cell. 2004 Aug 6;118(3):285-96
pubmed: 15294155
Nature. 2005 Mar 31;434(7033):605-11
pubmed: 15758953
Cell. 2010 Oct 1;143(1):134-44
pubmed: 20887898
Genesis. 2004 Jul;39(3):186-93
pubmed: 15282745
Nature. 2011 Jun 15;474(7351):337-42
pubmed: 21677750
Oncogene. 2017 Jul 13;36(28):3943-3956
pubmed: 28288132
Methods Mol Biol. 2017;1559:255-265
pubmed: 28063049
J Immunol. 2013 May 15;190(10):5306-12
pubmed: 23585682
Nat Immunol. 2009 Jan;10(1):83-91
pubmed: 19029903
J Biol Chem. 1998 Mar 6;273(10):5858-68
pubmed: 9488723
Cell. 2017 Nov 16;171(5):1029-1041.e21
pubmed: 29056346
Cell. 2011 Oct 28;147(3):629-40
pubmed: 21999944
Nature. 2015 Dec 24;528(7583):560-564
pubmed: 26649819
Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17858-63
pubmed: 16301529
Nat Biotechnol. 2010 May;28(5):511-5
pubmed: 20436464
Nature. 2016 Oct 13;538(7624):260-264
pubmed: 27698416
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Cell. 2018 Apr 5;173(2):371-385.e18
pubmed: 29625053
Immunity. 2018 Aug 21;49(2):353-362.e5
pubmed: 30119997
Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6731-6
pubmed: 8692887
J Exp Med. 2009 Jul 6;206(7):1465-72
pubmed: 19564350
Cell Stem Cell. 2008 Jun 5;2(6):576-83
pubmed: 18522850
Nature. 2009 Jan 29;457(7229):608-11
pubmed: 19092804
Science. 2004 Jul 9;305(5681):248-51
pubmed: 15247480
Nature. 2016 Jan 7;529(7584):43-7
pubmed: 26675728
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Nature. 2012 Nov 8;491(7423):259-63
pubmed: 23075849
Cancer Res. 1994 Feb 1;54(3):614-7
pubmed: 8306319
Cell Stem Cell. 2011 Jan 7;8(1):16-29
pubmed: 21211780
Genesis. 2000 Nov-Dec;28(3-4):106-10
pubmed: 11105051
Nat Immunol. 2011 Nov 20;13(2):144-51
pubmed: 22101730
Eur J Immunol. 2018 Jan;48(1):15-31
pubmed: 29178520
Mol Cell Biol. 2001 Mar;21(5):1621-32
pubmed: 11238899
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Arch Toxicol. 2014 Mar;88(3):823-36
pubmed: 24154822
Nat Rev Cancer. 2012 Jan 12;12(2):104-20
pubmed: 22237395
Science. 2011 Dec 16;334(6062):1561-5
pubmed: 22033518
J Cell Biol. 1979 Feb;80(2):248-65
pubmed: 88453
J Nutr Biochem. 2017 Oct;48:112-119
pubmed: 28810182
Nature. 2007 Oct 25;449(7165):1003-7
pubmed: 17934449
Science. 2008 Mar 7;319(5868):1352-5
pubmed: 18323444
J Immunol. 2007 Dec 15;179(12):8098-104
pubmed: 18056351
Carcinogenesis. 2000 Jun;21(6):1117-20
pubmed: 10836998
Eur J Immunol. 2017 Oct;47(10):1584-1797
pubmed: 29023707
Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9543-7
pubmed: 1658785
Anal Biochem. 2013 Mar 1;434(1):4-11
pubmed: 23142629
Int J Exp Pathol. 2010 Dec;91(6):506-14
pubmed: 20804538
Anal Chem. 2012 Jul 17;84(14):6256-62
pubmed: 22816785

Auteurs

Konrad Gronke (K)

Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Berlin Institute of Health (BIH), Berlin, Germany.
Mucosal and Developmental Immunology, Deutsches Rheuma-Forschungszentrum, Berlin, Germany.
Department of Medical Microbiology and Hygiene, University Medical Centre, University of Mainz, Mainz, Germany.
Department of Medical Microbiology, University of Freiburg, Freiburg, Germany.
Max Planck Institute for Immunobiology and Epigenetics, Freiburg, Germany.

Pedro P Hernández (PP)

Department of Medical Microbiology, University of Freiburg, Freiburg, Germany.
Max Planck Institute for Immunobiology and Epigenetics, Freiburg, Germany.
Macrophages and Development of Immunity, Institute Pasteur, Paris, France.

Jakob Zimmermann (J)

Department of Medical Microbiology, University of Freiburg, Freiburg, Germany.

Christoph S N Klose (CSN)

Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Department of Medical Microbiology, University of Freiburg, Freiburg, Germany.
Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA.

Michael Kofoed-Branzk (M)

Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Berlin Institute of Health (BIH), Berlin, Germany.
Mucosal and Developmental Immunology, Deutsches Rheuma-Forschungszentrum, Berlin, Germany.
Department of Medical Microbiology and Hygiene, University Medical Centre, University of Mainz, Mainz, Germany.
Department of Medical Microbiology, University of Freiburg, Freiburg, Germany.
Max Planck Institute for Immunobiology and Epigenetics, Freiburg, Germany.

Fabian Guendel (F)

Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Berlin Institute of Health (BIH), Berlin, Germany.
Mucosal and Developmental Immunology, Deutsches Rheuma-Forschungszentrum, Berlin, Germany.
Department of Medical Microbiology and Hygiene, University Medical Centre, University of Mainz, Mainz, Germany.
Department of Medical Microbiology, University of Freiburg, Freiburg, Germany.

Mario Witkowski (M)

Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Berlin Institute of Health (BIH), Berlin, Germany.
Mucosal and Developmental Immunology, Deutsches Rheuma-Forschungszentrum, Berlin, Germany.
Department of Medical Microbiology and Hygiene, University Medical Centre, University of Mainz, Mainz, Germany.

Caroline Tizian (C)

Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Berlin Institute of Health (BIH), Berlin, Germany.
Mucosal and Developmental Immunology, Deutsches Rheuma-Forschungszentrum, Berlin, Germany.
Department of Medical Microbiology and Hygiene, University Medical Centre, University of Mainz, Mainz, Germany.

Lukas Amann (L)

Department of Medical Microbiology, University of Freiburg, Freiburg, Germany.
Institute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany.

Fabian Schumacher (F)

Department of Nutritional Toxicology, Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany.
Department of Molecular Biology, University of Duisburg-Essen, Essen, Germany.

Hansruedi Glatt (H)

German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Potsdam, Germany.
Department Food Safety, Federal Institute for Risk Assessment, Berlin, Germany.

Antigoni Triantafyllopoulou (A)

Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Innate Immunity in Rheumatic Diseases, Deutsches Rheuma-Forschungszentrum, Berlin, Germany.

Andreas Diefenbach (A)

Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany. andreas.diefenbach@charite.de.
Berlin Institute of Health (BIH), Berlin, Germany. andreas.diefenbach@charite.de.
Mucosal and Developmental Immunology, Deutsches Rheuma-Forschungszentrum, Berlin, Germany. andreas.diefenbach@charite.de.
Department of Medical Microbiology and Hygiene, University Medical Centre, University of Mainz, Mainz, Germany. andreas.diefenbach@charite.de.
Department of Medical Microbiology, University of Freiburg, Freiburg, Germany. andreas.diefenbach@charite.de.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Interleukin-22 protects intestinal stem cells...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Interleukin-22 protects intestinal stem cells...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › Transformation cellulaire néoplasique › Interleukin-22 protects intestinal stem cells...
questionsmedicales.fr › Système digestif › Tube digestif › Tube digestif inférieur › Gros intestin › Côlon › Interleukin-22 protects intestinal stem cells...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Tumeurs de l'intestin › Tumeurs du côlon › Interleukin-22 protects intestinal stem cells...
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › Interleukin-22 protects intestinal stem cells...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Interleukin-22 protects intestinal stem cells...
questionsmedicales.fr › Glucides › Hétérosides › Thioglycosides › Thioglucosides › Glucosinolates › Interleukin-22 protects intestinal stem cells...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › Interleukin-22 protects intestinal stem cells...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukin-22 protects intestinal stem cells...
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse intestinale › Interleukin-22 protects intestinal stem cells...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Interleukin-22 protects intestinal stem cells...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Interleukin-22 protects intestinal stem cells...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Noxas › Mutagènes › Interleukin-22 protects intestinal stem cells...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Interleukin-22 protects intestinal stem cells...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Récepteurs à hydrocarbure aromatique › Interleukin-22 protects intestinal stem cells...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux interleukines › Interleukin-22 protects intestinal stem cells...
questionsmedicales.fr › Cellules › Cellules souches › Interleukin-22 protects intestinal stem cells...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Interleukin-22 protects intestinal stem cells...