ABC transporters Mdr1a/1b, Bcrp1, Mrp2 and Mrp3 determine the sensitivity to PhIP/DSS-induced colon carcinogenesis and inflammation.
ABC transporters
Carcinogenesis
Colon cancer
DSS
Inflammation
PhIP
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
10
10
2018
accepted:
10
01
2019
pubmed:
1
2
2019
medline:
19
5
2020
entrez:
1
2
2019
Statut:
ppublish
Résumé
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is an abundant dietary carcinogen, formed during high-temperature cooking of meat. In this study, we investigated whether clinically relevant ATP-binding cassette (ABC) efflux transporters can modulate PhIP-induced colorectal carcinogenesis in vivo using wild-type (WT), Bcrp1
Identifiants
pubmed: 30701287
doi: 10.1007/s00204-019-02394-w
pii: 10.1007/s00204-019-02394-w
doi:
Substances chimiques
ATP-Binding Cassette Transporters
0
Carcinogens
0
Imidazoles
0
Dextran Sulfate
9042-14-2
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
909C6UN66T
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM