Impact of influenza on hospitalization rates in children with a range of chronic lung diseases.

Child Child, Preschool Chronic Disease Female Hospitalization / statistics & numerical data Humans Incidence Infant Infant, Newborn Influenza, Human / epidemiology Lung Diseases / complications Male New South Wales / epidemiology Retrospective Studies
chronic lung diseases influenza burden pediatrics

Journal

Influenza and other respiratory viruses
ISSN: 1750-2659
Titre abrégé: Influenza Other Respir Viruses
Pays: England
ID NLM: 101304007

Informations de publication

Date de publication:
05 2019
Historique:
received: 29 08 2018
revised: 19 12 2018
accepted: 31 12 2018
pubmed: 1 2 2019
medline: 18 12 2019
entrez: 1 2 2019
Statut: ppublish

Résumé

Data on burden of severe influenza in children with a range of chronic lung diseases (CLDs) remain limited. We performed a cohort study to estimate burden of influenza-associated hospitalization in children with CLDs using population-based linked data. The cohort comprised all children in New South Wales, Australia, born between 2001 and 2010 and was divided into five groups, children with: (a) severe asthma; (b) bronchopulmonary dysplasia (BPD); (c) cystic fibrosis (CF); (d) other congenital/chronic lung conditions; and (e) children without CLDs. Incidence rates and rate ratios for influenza-associated hospitalization were calculated for 2001-2011. Average cost/episode of hospitalization was estimated using public hospital cost weights. Our cohort comprised 888 157 children; 11 058 (1.2%) had one of the CLDs. The adjusted incidence/1000 child-years of influenza-associated hospitalization in children with CLDs was 3.9 (95% CI: 2.6-5.2) and 0.7 (95% CI: 0.5-0.9) for children without. The rate ratio was 5.4 in children with CLDs compared to children without. The adjusted incidence/1000 child-years (95% CI) in children with severe asthma was 1.1 (0.6-1.6), with BPD was 6.0 (3.7-8.3), with CF was 7.4 (2.6-12.1), and with other congenital/chronic lung conditions was 6.9 (4.9-8.9). The cost/episode (95% CI) of influenza-associated hospitalization was AUD 19 704 (95% CI: 11 715-27 693) for children with CLDs compared to 4557 (95% CI: 4129-4984) for children without. This large population-based study suggests a significant healthcare burden associated with influenza in children with a range of CLDs.

Sections du résumé

BACKGROUND
Data on burden of severe influenza in children with a range of chronic lung diseases (CLDs) remain limited.
METHOD
We performed a cohort study to estimate burden of influenza-associated hospitalization in children with CLDs using population-based linked data. The cohort comprised all children in New South Wales, Australia, born between 2001 and 2010 and was divided into five groups, children with: (a) severe asthma; (b) bronchopulmonary dysplasia (BPD); (c) cystic fibrosis (CF); (d) other congenital/chronic lung conditions; and (e) children without CLDs. Incidence rates and rate ratios for influenza-associated hospitalization were calculated for 2001-2011. Average cost/episode of hospitalization was estimated using public hospital cost weights.
RESULTS
Our cohort comprised 888 157 children; 11 058 (1.2%) had one of the CLDs. The adjusted incidence/1000 child-years of influenza-associated hospitalization in children with CLDs was 3.9 (95% CI: 2.6-5.2) and 0.7 (95% CI: 0.5-0.9) for children without. The rate ratio was 5.4 in children with CLDs compared to children without. The adjusted incidence/1000 child-years (95% CI) in children with severe asthma was 1.1 (0.6-1.6), with BPD was 6.0 (3.7-8.3), with CF was 7.4 (2.6-12.1), and with other congenital/chronic lung conditions was 6.9 (4.9-8.9). The cost/episode (95% CI) of influenza-associated hospitalization was AUD 19 704 (95% CI: 11 715-27 693) for children with CLDs compared to 4557 (95% CI: 4129-4984) for children without.
DISCUSSION
This large population-based study suggests a significant healthcare burden associated with influenza in children with a range of CLDs.

Identifiants

DOI: 10.1111/irv.12633 PMID: 30701672 PMC: PMC6468072
pubmed: 30701672
doi: 10.1111/irv.12633
pmc: PMC6468072
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

233-239

Informations de copyright

© 2019 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.

Références

J Infect Dis. 2006 Nov 1;194 Suppl 2:S133-8
pubmed: 17163386
Pediatr Infect Dis J. 2005 Oct;24(10):931-2
pubmed: 16220098
J Pediatr. 1997 Mar;130(3):400-8
pubmed: 9063415
Pediatrics. 2002 May;109(5):E80-0
pubmed: 11986486
J Am Geriatr Soc. 2002 Apr;50(4):608-16
pubmed: 11982659
Thorax. 1992 Feb;47(2):112-4
pubmed: 1549818
Clin Infect Dis. 2017 Jun 15;64(12):1760-1767
pubmed: 28329304
Pediatrics. 1988 Aug;82(2):199-203
pubmed: 3399292
Allergy. 2007 Feb;62(2):102-12
pubmed: 17298416
Epidemiol Infect. 2016 Jun;144(8):1612-21
pubmed: 26626237
Am J Respir Crit Care Med. 1995 May;151(5):1682-5; discussion 1685-6
pubmed: 7735634
Cochrane Database Syst Rev. 2009 Oct 07;(4):CD001753
pubmed: 19821281
Influenza Other Respir Viruses. 2019 May;13(3):233-239
pubmed: 30701672
N Engl J Med. 2000 Jan 27;342(4):232-9
pubmed: 10648764
Chest. 2010 Apr;137(4):852-60
pubmed: 19965953
Pediatrics. 2008 Jan;121(1):1-8
pubmed: 18166550
N Engl J Med. 1984 Dec 27;311(26):1653-8
pubmed: 6504106
BMJ. 2014 Apr 09;348:g2371
pubmed: 24811409
J Pediatr. 2000 Dec;137(6):856-64
pubmed: 11113844
Expert Rev Vaccines. 2013 Apr;12(4):415-20
pubmed: 23560921
BJOG. 2015 Sep;122(10):1303-11
pubmed: 25754325
Pediatrics. 2013 Dec;132(6):e1539-45
pubmed: 24276847
Pediatr Pulmonol. 1990;8(4):226-32
pubmed: 2371071
N Engl J Med. 2008 Oct 9;359(15):1555-64
pubmed: 18799552
Semin Neonatol. 2003 Feb;8(1):63-71
pubmed: 12667831
Vaccine. 2008 Oct 16;26(44):5612-8
pubmed: 18721838
Arch Pediatr Adolesc Med. 2006 Jul;160(7):713-8
pubmed: 16818837
Med J Aust. 1998 Oct 19;169(S1):S32-5
pubmed: 9830408
J Pediatr. 2014 Jan;164(1):40-45.e4
pubmed: 24055328
Indian J Pediatr. 2007 May;74(5):477-82
pubmed: 17526960

Auteurs

Nusrat Homaira (N)

Faculty of Medicine, Discipline of Pediatrics, School of Women's and Children's Health, UNSW Sydney, Sydney, New South Wales, Australia.
Respiratory Department, Sydney Children's Hospital, Sydney, New South Wales, Australia.
ORCID: 0000-0003-3341-7964

Nancy Briggs (N)

Stats Central, Mark Wainwright Analytical Centre, UNSW Sydney, Sydney, New South Wales, Australia.

Ju-Lee Oei (JL)

Faculty of Medicine, Discipline of Pediatrics, School of Women's and Children's Health, UNSW Sydney, Sydney, New South Wales, Australia.
Department of Newborn Care, Royal Hospital for Women, Sydney, New South Wales, Australia.

Lisa Hilder (L)

Faculty of Medicine, Discipline of Pediatrics, School of Women's and Children's Health, UNSW Sydney, Sydney, New South Wales, Australia.
Centre for Big Data Research in Health UNSW Sydney, Sydney, New South Wales, Australia.

Barbara Bajuk (B)

NSW Pregnancy and Newborn Services Network, Sydney Children's Hospitals Network, Sydney, New South Wales, Australia.

Tom Snelling (T)

Princess Margaret Hospital, Perth, Western Australia, Australia.
Wesfarmers Centre of Vaccines & Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.
Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
School of Public Health, Curtin University, Bentley, Western Australia, Australia.

Georgina M Chambers (GM)

Faculty of Medicine, Discipline of Pediatrics, School of Women's and Children's Health, UNSW Sydney, Sydney, New South Wales, Australia.
Centre for Big Data Research in Health UNSW Sydney, Sydney, New South Wales, Australia.
National Perinatal Epidemiology and Statistics Unit (NPESU), Kensington, New South Wales, Australia.

Adam Jaffe (A)

Faculty of Medicine, Discipline of Pediatrics, School of Women's and Children's Health, UNSW Sydney, Sydney, New South Wales, Australia.
Respiratory Department, Sydney Children's Hospital, Sydney, New South Wales, Australia.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Impact of influenza on hospitalization rates...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Impact of influenza on hospitalization rates...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Impact of influenza on hospitalization rates...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Soins aux patients › Hospitalisation › Impact of influenza on hospitalization rates...
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questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Impact of influenza on hospitalization rates...
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