Pharmacoepidemiology of statins.

Cardiovascular Diseases / etiology Cholesterol / metabolism Clinical Trials as Topic / statistics & numerical data Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage Medication Adherence / statistics & numerical data Pharmacoepidemiology
Cardiovascular prevention Cholesterol Pharmacoepidemiology Real-world evidence Statin

Journal

Therapie
ISSN: 1958-5578
Titre abrégé: Therapie
Pays: France
ID NLM: 0420544

Informations de publication

Date de publication:
Apr 2019
Historique:
received: 24 09 2018
accepted: 29 09 2018
pubmed: 2 2 2019
medline: 18 7 2019
entrez: 2 2 2019
Statut: ppublish

Résumé

The evaluation of the real-life benefits and risks of statins in population is a major pharmacoepidemiological issue, given their widespread use for cardiovascular prevention. The purpose of this review was not to be exhaustive but to show the contributions of pharmacoepidemiology for various aspects of the evaluation of statins such as real-life drug use, effectiveness and risk. Statins are among the most used drugs in the world, but recent data show a slight decrease in use. Actual statin users are older, and have more comorbidities than those studied in clinical trials, but this does not seem to compromise their effectiveness, unlike the compliance issues that are common with these drugs. Beyond the known adverse reactions of statins from the clinical trials, risks of statins can be varied and sometimes difficult to evaluate, considering the ubiquity of cholesterol throughout the body, from drug or endogenous molecule metabolism to the construction of cell membranes or cell activities.

Identifiants

DOI: 10.1016/j.therap.2019.01.004 PMID: 30704765
pubmed: 30704765
pii: S0040-5957(19)30008-3
doi: 10.1016/j.therap.2019.01.004
pii:
doi:

Substances chimiques

Hydroxymethylglutaryl-CoA Reductase Inhibitors 0
Cholesterol 97C5T2UQ7J

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

261-269

Informations de copyright

Copyright © 2019 Société française de pharmacologie et de thérapeutique. Published by Elsevier Masson SAS. All rights reserved.

Auteurs

Julien Bezin (J)

Inserm, UMR 1219, Bordeaux population health research center, team pharmacoepidemiology, université Bordeaux, 33076 Bordeaux, France. Electronic address: julien.bezin@u-bordeaux.fr.

Nicholas Moore (N)

Inserm CIC1401, Inserm CR1219, Bordeaux PharmacoEpi, université et CHU de Bordeaux, 33076 Bordeaux, France.

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Classifications MeSH

questionsmedicales.fr › Maladies cardiovasculaires › Pharmacoepidemiology of statins.
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholestérol › Pharmacoepidemiology of statins.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Pharmacoepidemiology of statins.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Pharmacoepidemiology of statins.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents régulateurs du métabolisme des lipides › Hypolipémiants › Anticholestérolémiants › Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase › Pharmacoepidemiology of statins.
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Prestations des soins de santé › Attitude envers la santé › Adhésion et observance thérapeutiques › Acceptation des soins par les patients › Observance par le patient › Adhésion au traitement médicamenteux › Pharmacoepidemiology of statins.
questionsmedicales.fr › Professions de santé › Pharmacologie › Pharmacoépidémiologie › Pharmacoepidemiology of statins.