Metabolic Acidosis 1 Year Following Kidney Transplantation and Subsequent Cardiovascular Events and Mortality: An Observational Cohort Study.
Acidosis
/ complications
Adult
Cardiovascular Diseases
/ epidemiology
Cause of Death
/ trends
Female
Follow-Up Studies
Humans
Kidney Failure, Chronic
/ therapy
Kidney Transplantation
/ adverse effects
Male
Middle Aged
Prevalence
Renal Dialysis
Retrospective Studies
Risk Assessment
/ methods
Risk Factors
Survival Rate
/ trends
Time Factors
Wisconsin
/ epidemiology
Metabolic acidosis
arrhythmia
cardiovascular events (CVE)
coronary artery disease
heart failure
hypobicarbonatemia
kidney transplantation
mortality
myocardial infarction
serum bicarbonate
total CO(2)
Journal
American journal of kidney diseases : the official journal of the National Kidney Foundation
ISSN: 1523-6838
Titre abrégé: Am J Kidney Dis
Pays: United States
ID NLM: 8110075
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
19
04
2018
accepted:
02
12
2018
pubmed:
2
2
2019
medline:
1
2
2020
entrez:
2
2
2019
Statut:
ppublish
Résumé
Recent studies suggest that metabolic acidosis is associated with mortality and graft failure in kidney transplant recipients. However, it is unknown whether serum bicarbonate (measured as total carbon dioxide [tCO Observational cohort study. Single-center study of 2,128 kidney transplant recipients free of CVEs during the first 13.5 months following transplantation. tCO Ischemic, arrhythmic, and heart failure CVEs and death from any cause. Independent associations were assessed using multivariable proportional hazards regression models. Restricted cubic spline Poisson models were used to explore nonlinear associations. Linear spline proportional hazards models were used to assess associations at different tCO The prevalence of metabolic acidosis defined as tCO Single-center observational study. Metabolic acidosis is an independent risk factor for ischemic CVEs after kidney transplantation. It is unknown whether correction of acidosis improves outcomes in these patients.
Identifiants
pubmed: 30704880
pii: S0272-6386(19)30002-2
doi: 10.1053/j.ajkd.2018.12.023
pii:
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
476-485Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.