Linking a mutation to survival in wild mice.

Agouti Signaling Protein / genetics Animals Gene Frequency Genotype Hair Color / genetics Melanins / analysis Mice, Inbred C57BL Mice, Transgenic Mutation Nebraska Peromyscus / genetics Phenotype Pigmentation / genetics Selection, Genetic Sequence Deletion

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
01 02 2019
Historique:
received: 25 09 2018
accepted: 06 12 2018
entrez: 2 2 2019
pubmed: 2 2 2019
medline: 2 8 2019
Statut: ppublish

Résumé

Adaptive evolution in new or changing environments can be difficult to predict because the functional connections between genotype, phenotype, and fitness are complex. Here, we make these explicit connections by combining field and laboratory experiments in wild mice. We first directly estimate natural selection on pigmentation traits and an underlying pigment locus,

Identifiants

DOI: 10.1126/science.aav3824 PMID: 30705186
pubmed: 30705186
pii: 363/6426/499
doi: 10.1126/science.aav3824
doi:

Substances chimiques

Agouti Signaling Protein 0
Melanins 0
pheomelanin 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Pagination

499-504

Subventions

Organisme : World Health Organization
ID : 001
Pays : International
Organisme : Howard Hughes Medical Institute
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Auteurs

Rowan D H Barrett (RDH)

Redpath Museum and Department of Biology, McGill University, Montreal, Canada. rowan.barrett@mcgill.ca hoekstra@oeb.harvard.edu.
ORCID: 0000-0003-3044-2531

Stefan Laurent (S)

School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
ORCID: 0000-0003-4016-5427

Ricardo Mallarino (R)

Department of Organismic and Evolutionary Biology, Museum of Comparative Zoology, Harvard University, Cambridge, MA USA.
Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.
ORCID: 0000-0002-8971-4864

Susanne P Pfeifer (SP)

School of Life Sciences, Center for Evolution and Medicine, Arizona State University, Tempe, AZ, USA.
ORCID: 0000-0003-1378-2913

Charles C Y Xu (CCY)

Redpath Museum and Department of Biology, McGill University, Montreal, Canada.
ORCID: 0000-0001-6779-8879

Matthieu Foll (M)

International Agency for Research on Cancer, World Health Organization, Lyon, France.
ORCID: 0000-0001-9006-8436

Kazumasa Wakamatsu (K)

Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Japan.
ORCID: 0000-0003-1748-9001

Jonathan S Duke-Cohan (JS)

Department of Medical Oncology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-9478-9609

Jeffrey D Jensen (JD)

School of Life Sciences, Center for Evolution and Medicine, Arizona State University, Tempe, AZ, USA.
ORCID: 0000-0002-4786-8064

Hopi E Hoekstra (HE)

Department of Organismic and Evolutionary Biology, Museum of Comparative Zoology, Harvard University, Cambridge, MA USA. rowan.barrett@mcgill.ca hoekstra@oeb.harvard.edu.
Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.
ORCID: 0000-0003-1431-1769

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéine de signalisation Agouti › Linking a mutation to survival in wild mice.
questionsmedicales.fr › Eucaryotes › Animaux › Linking a mutation to survival in wild mice.
questionsmedicales.fr › Phénomènes génétiques › Fréquence d'allèle › Linking a mutation to survival in wild mice.
questionsmedicales.fr › Phénomènes génétiques › Génotype › Linking a mutation to survival in wild mice.
questionsmedicales.fr › Phénomènes biologiques › Pigmentation › Couleur des cheveux › Linking a mutation to survival in wild mice.
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Mélanines › Linking a mutation to survival in wild mice.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Linking a mutation to survival in wild mice.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Linking a mutation to survival in wild mice.
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Linking a mutation to survival in wild mice.
questionsmedicales.fr › Régions géographiques › Amériques › Amérique du Nord › États-Unis › États du Centre-Ouest des États-Unis › Nébraska › Linking a mutation to survival in wild mice.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Sigmodontinae › Peromyscus › Linking a mutation to survival in wild mice.
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Linking a mutation to survival in wild mice.
questionsmedicales.fr › Phénomènes biologiques › Pigmentation › Linking a mutation to survival in wild mice.
questionsmedicales.fr › Phénomènes génétiques › Sélection génétique › Linking a mutation to survival in wild mice.
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Délétion de séquence › Linking a mutation to survival in wild mice.