Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease.
Adaptor Proteins, Signal Transducing
/ genetics
Aged
Aged, 80 and over
Alzheimer Disease
/ ethnology
Argentina
/ ethnology
Black People
/ genetics
Female
Genetic Predisposition to Disease
Genetic Variation
Genome-Wide Association Study
Genotype
Humans
Indians, North American
/ genetics
Male
Membrane Glycoproteins
/ genetics
Middle Aged
Phospholipase C gamma
/ genetics
Receptors, Immunologic
/ genetics
White People
/ genetics
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
31 01 2019
31 01 2019
Historique:
received:
02
08
2018
accepted:
01
01
2019
revised:
26
11
2018
entrez:
2
2
2019
pubmed:
2
2
2019
medline:
14
6
2019
Statut:
epublish
Résumé
Rare coding variants in TREM2, PLCG2, and ABI3 were recently associated with the susceptibility to Alzheimer's disease (AD) in Caucasians. Frequencies and AD-associated effects of variants differ across ethnicities. To start filling the gap on AD genetics in South America and assess the impact of these variants across ethnicity, we studied these variants in Argentinian population in association with ancestry. TREM2 (rs143332484 and rs75932628), PLCG2 (rs72824905), and ABI3 (rs616338) were genotyped in 419 AD cases and 486 controls. Meta-analysis with European population was performed. Ancestry was estimated from genome-wide genotyping results. All variants show similar frequencies and odds ratios to those previously reported. Their association with AD reach statistical significance by meta-analysis. Although the Argentinian population is an admixture, variant carriers presented mainly Caucasian ancestry. Rare coding variants in TREM2, PLCG2, and ABI3 also modulate susceptibility to AD in populations from Argentina, and they may have a European heritage.
Identifiants
pubmed: 30705288
doi: 10.1038/s41398-019-0394-9
pii: 10.1038/s41398-019-0394-9
pmc: PMC6355764
doi:
Substances chimiques
ABI3 protein, human
0
Adaptor Proteins, Signal Transducing
0
Membrane Glycoproteins
0
Receptors, Immunologic
0
TREM2 protein, human
0
Phospholipase C gamma
EC 3.1.4.3
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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