Intravoxel incoherent motion MRI for discrimination of synovial proliferation in the hand arthritis: A prospective proof-of-concept study.
Adult
Aged
Arthritis
/ diagnostic imaging
Cell Proliferation
Female
Hand Joints
/ diagnostic imaging
Humans
Image Interpretation, Computer-Assisted
/ methods
Magnetic Resonance Imaging
/ methods
Male
Middle Aged
Prospective Studies
Reproducibility of Results
Severity of Illness Index
Synovial Membrane
/ diagnostic imaging
MRI
arthritis
diffusion weighted imaging
intravoxel incoherent motion
synovial proliferation
Journal
Journal of magnetic resonance imaging : JMRI
ISSN: 1522-2586
Titre abrégé: J Magn Reson Imaging
Pays: United States
ID NLM: 9105850
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
14
11
2018
revised:
07
01
2019
accepted:
08
01
2019
pubmed:
2
2
2019
medline:
21
10
2020
entrez:
2
2
2019
Statut:
ppublish
Résumé
Postcontrast-enhanced MRI is currently the reference standard for synovial proliferation in rheumatoid arthritis (RA). However, the technique is somewhat invasive due to the use of gadolinium contrast agents, which may cause severe adverse/side effects. Intravoxel incoherent motion (IVIM) simultaneously permits quantification of perfusion as well as diffusion using a single imaging scan. To test the capability of IVIM MRI for noninvasive discrimination of synovial proliferation in hand arthritis. Prospective. Seven suspected RA patients (three women and four men; mean age, 61 years; range, 26-74 years). 3 T/short tau inversion recovery (STIR), IVIM, postcontrast-enhanced MRI. Region of interest (ROI) was identified based on STIR. Contrast-enhanced MRI was evaluated using a 5-point grading scale of 0 (water) to 4 (synovial proliferation) according to the degree of contrast enhancement within the ROI. For each ROI, we calculated the apparent diffusion coefficient (ADC) and IVIM parameters (molecular diffusion coefficient [D], perfusion fraction [f], and perfusion-related diffusion coefficient [D*]). These parameters were subsequently compared with ROI contrast enhancement grades. Spearman's rank correlation test and a receiver operating characteristic (ROC) curve. A total of 90 ROIs of suspected synovial proliferation and/or joint effusion were identified. ROI grades were correlated with ADC and D values (r The IVIM parameter D and ADC may be useful for the noninvasive identification of synovial proliferation in hand arthritis. 2 Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2019;50:1199-1206.
Sections du résumé
BACKGROUND
Postcontrast-enhanced MRI is currently the reference standard for synovial proliferation in rheumatoid arthritis (RA). However, the technique is somewhat invasive due to the use of gadolinium contrast agents, which may cause severe adverse/side effects. Intravoxel incoherent motion (IVIM) simultaneously permits quantification of perfusion as well as diffusion using a single imaging scan.
PURPOSE/HYPOTHESIS
To test the capability of IVIM MRI for noninvasive discrimination of synovial proliferation in hand arthritis.
STUDY TYPE
Prospective.
SUBJECTS
Seven suspected RA patients (three women and four men; mean age, 61 years; range, 26-74 years).
FIELD STRENGTH/SEQUENCE
3 T/short tau inversion recovery (STIR), IVIM, postcontrast-enhanced MRI.
ASSESSMENT
Region of interest (ROI) was identified based on STIR. Contrast-enhanced MRI was evaluated using a 5-point grading scale of 0 (water) to 4 (synovial proliferation) according to the degree of contrast enhancement within the ROI. For each ROI, we calculated the apparent diffusion coefficient (ADC) and IVIM parameters (molecular diffusion coefficient [D], perfusion fraction [f], and perfusion-related diffusion coefficient [D*]). These parameters were subsequently compared with ROI contrast enhancement grades.
STATISTICAL TESTS
Spearman's rank correlation test and a receiver operating characteristic (ROC) curve.
RESULTS
A total of 90 ROIs of suspected synovial proliferation and/or joint effusion were identified. ROI grades were correlated with ADC and D values (r
DATA CONCLUSION
The IVIM parameter D and ADC may be useful for the noninvasive identification of synovial proliferation in hand arthritis.
LEVEL OF EVIDENCE
2 Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2019;50:1199-1206.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1199-1206Informations de copyright
© 2019 International Society for Magnetic Resonance in Medicine.
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