Diagnoses of Pathological States Based on Acetylcholinesterase and Butyrylcholinesterase.
Acetylcholinesterase
anesthesia
butyrylcholinesterase
diagnosis
liver function test
myorelaxant
nerve agent
neurotransmission
pesticide
poisoning.
Journal
Current medicinal chemistry
ISSN: 1875-533X
Titre abrégé: Curr Med Chem
Pays: United Arab Emirates
ID NLM: 9440157
Informations de publication
Date de publication:
2020
2020
Historique:
received:
01
07
2018
revised:
16
01
2019
accepted:
17
01
2019
pubmed:
2
2
2019
medline:
6
8
2020
entrez:
2
2
2019
Statut:
ppublish
Résumé
Two cholinesterases exist: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). While AChE plays a crucial role in neurotransmissions, BChE has no specific function apart from the detoxification of some drugs and secondary metabolites from plants. Thus, both AChE and BChE can serve as biochemical markers of various pathologies. Poisoning by nerve agents like sarin, soman, tabun, VX, novichok and overdosing by drugs used in some neurodegenerative disorders like Alzheimer´s disease and myasthenia gravis, as well as poisoning by organophosphorus pesticides are relevant to this issue. But it appears that changes in these enzymes take place in other processes including oxidative stress, inflammation, some types of cancer and genetically conditioned diseases. In this review, the cholinesterases are introduced, the mechanism of inhibitors action is explained and the relations between the cholinesterases and pathologies are explained.
Identifiants
pubmed: 30706778
pii: CMC-EPUB-96228
doi: 10.2174/0929867326666190130161202
doi:
Substances chimiques
Cholinesterase Inhibitors
0
Pesticides
0
Acetylcholinesterase
EC 3.1.1.7
Butyrylcholinesterase
EC 3.1.1.8
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2994-3011Informations de copyright
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